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Cellosaurus CAL-72 (CVCL_1113)

[Text version]
Cell line name CAL-72
Synonyms CAL 72; CAL72; Cal72; Centre Antoine Lacassagne-72
Accession CVCL_1113
Resource Identification Initiative To cite this cell line use: CAL-72 (RRID:CVCL_1113)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: African.
Doubling time: 66 hours (Note=At 17th passage) (PubMed=10389764); ~40-50 hours (DSMZ=ACC-439).
Karyotypic information: Has lost chromosome Y (PubMed=10389764).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone, patella; UBERON=UBERON_0002446.
Genome ancestry Source: PubMed=30894373

Origin% genome
African67.94
Native American0.09
East Asian, North1.27
East Asian, South0
South Asian24.79
European, North0
European, South5.91
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; DSMZ

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133821
D3S135818
D5S81813
D7S82011
D8S117911,14
D13S3178
D16S53910
D18S5119
D19S43313
D21S1128
FGA19,22
Penta D8
Penta E15,19
TH018
TPOX11
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=10389764; DOI=10.1002/(SICI)1097-0215(19990719)82:2<282::AID-IJC20>3.0.CO;2-R
Rochet N., Dubousset J., Mazeau C., Zanghellini E., Farges M.-F., Stora de Novion H., Chompret A., Delpech B., Cattan N., Frenay M., Gioanni J.
Establishment, characterisation and partial cytokine expression profile of a new human osteosarcoma cell line (CAL 72).
Int. J. Cancer 82:282-285(1999)

PubMed=11668190; DOI=10.1177/002215540104901105
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=12631258; DOI=10.1034/j.1600-0609.2003.02766.x
Rochet N., Leroy P., Far D.F., Ollier L., Loubat A., Rossi B.
CAL72: a human osteosarcoma cell line with unique effects on hematopoietic cells.
Eur. J. Haematol. 70:43-52(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-439
Cell line databases/resources CLO; CLO_0002188
cancercelllines; CVCL_1113
Cell_Model_Passport; SIDM00930
Cosmic-CLP; 906827
DepMap; ACH-001715
DSMZCellDive; ACC-439
LINCS_LDP; LCL-1419
Anatomy/cell type resources BTO; BTO:0002089
Biological sample resources BioSample; SAMN03473545
CRISP screens repositories BioGRID_ORCS_Cell_line; 842
Chemistry resources ChEMBL-Cells; CHEMBL3308718
ChEMBL-Targets; CHEMBL1075414
GDSC; 906827
PharmacoDB; CAL72_175_2019
PubChem_Cell_line; CVCL_1113
Encyclopedic resources Wikidata; Q54808412
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM320825
GEO; GSM1669655
Polymorphism and mutation databases Cosmic; 906827
Cosmic; 1074399
IARC_TP53; 21214
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number37