ID   CAL-39
AC   CVCL_1109
SY   CAL 39; CAL39; Centre Antoine Lacassagne-39
DR   CLO; CLO_0002184
DR   CLDB; cl630
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03473368
DR   cancercelllines; CVCL_1109
DR   Cell_Model_Passport; SIDM00935
DR   ChEMBL-Cells; CHEMBL3308716
DR   ChEMBL-Targets; CHEMBL1075410
DR   Cosmic; 924107
DR   Cosmic; 1995358
DR   Cosmic-CLP; 924107
DR   DepMap; ACH-002091
DR   DSMZ; ACC-187
DR   DSMZCellDive; ACC-187
DR   EGA; EGAS00001000978
DR   GDSC; 924107
DR   GEO; GSM1669651
DR   IARC_TP53; 27146
DR   LINCS_LDP; LCL-1294
DR   PharmacoDB; CAL39_171_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1109
DR   Wikidata; Q54808399
RX   PubMed=20164919;
RX   PubMed=21573363;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Doubling time: 30 hours (Note=At 34th passage) (PubMed=21573363); ~50-70 hours (DSMZ=ACC-187).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Arg2597Ter (c.7789C>T); ClinVar=VCV001937208; Zygosity=Homozygous (Cosmic-CLP=924107; DepMap=ACH-002091).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro151His (c.452C>A); ClinVar=VCV000376639; Zygosity=Homozygous (Cosmic-CLP=924107; DepMap=ACH-002091).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=2.88%; Native American=0.78%; East Asian, North=0%; East Asian, South=1.64%; South Asian=9.08%; European, North=26.43%; European, South=59.19% (PubMed=30894373).
CC   Derived from site: In situ; Vulva; UBERON=UBERON_0000997.
ST   Source(s): Cosmic-CLP=924107; DSMZ=ACC-187
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 12,13
ST   D16S539: 9,11
ST   D18S51: 16,17
ST   D19S433: 13
ST   D21S11: 30
ST   D2S1338: 21
ST   D3S1358: 17
ST   D5S818: 12
ST   D7S820: 8
ST   D8S1179: 16
ST   FGA: 21
ST   Penta D: 12,13
ST   Penta E: 7,12
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C4052; Vulvar squamous cell carcinoma
DI   ORDO; Orphanet_494448; Vulvar squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   76Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 39
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=21573363; DOI=10.3892/ijo.3.2.293;
RA   Gioanni, Jeannine
RA   Grosgeorge, Josiane
RA   Zanghellini, Evelyne
RA   Mazeau, Christiane
RA   Gaudray, Patrick
RA   Ettore, Francette
RA   Formento, Patricia
RA   Demard, Francois
RT   "Characterization of CAL39, a new human cell-line derived from a
RT   vulvar squamous-cell carcinoma.";
RL   Int. J. Oncol. 3:293-297(1993).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//