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Cellosaurus BONNA-12 (CVCL_1090)

[Text version]
Cell line name BONNA-12
Synonyms Bonna-12; BONNA12; Bonna12
Accession CVCL_1090
Resource Identification Initiative To cite this cell line use: BONNA-12 (RRID:CVCL_1090)
Comments Problematic cell line: Possibly misidentified. It is not certain that this cell line originate from a hairy cell leukemia (PubMed=22653958).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: 36-48 hours (PubMed=27463354); ~50-60 hours (DSMZ=ACC-150).
Karyotypic information: Has lost chromosome Y.
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Spleen; UBERON=UBERON_0002106.
Sequence variations
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Thr2466Met (c.7397C>T); ClinVar=VCV000241169; Zygosity=Heterozygous (PubMed=29989027; Cosmic-CLP; DepMap).
HLA typing Source: DSMZCellDive=ACC-150
Class I
Class II
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North1.04
East Asian, South0
South Asian0
European, North71.7
European, South26.91
Disease Hairy cell leukemia (NCIt: C7402)
Classic hairy cell leukemia (ORDO: Orphanet_58017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; DSMZ

D16S53911,12 (DSMZ)
12 (Cosmic-CLP; DepMap)
D18S5113 (DSMZ)
14 (DepMap)
Penta D9,11 (DSMZ)
9,12 (DepMap)
Penta E10,11 (DSMZ)
11 (DepMap)

Run an STR similarity search on this cell line

PubMed=27463354; DOI=10.3109/10428199109067637
Wientjens G.-J.H.M., Jansen J.H., Wessels H.W., Kibbelaar R.E., Beverstock G.C., Brederoo P., Kluin-Nelemans H.C.
Characterization of a new human B cell line (Bonna-12) with trisomy 9 and trisomy 12 chromosomal abnormality.
Leuk. Lymphoma 5:415-422(1991)

Kluin-Nelemans H.C., Wientjens G.-J.H.M., Jansen J.H.
Establishment of a new human B-cell line (BONNA-12) with trisomy 9 and trisomy 12 chromosomal abnormality.
Leukemia 6:158-158(1992)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=22653958; DOI=10.1182/blood-2011-12-400374
Tiacci E., Pucciarini A., Bigerna B., Pettirossi V., Strozzini F., Martelli M.P., Tabarrini A., Drexler H.G., Falini B.
Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M, and HC-1 questions their origin from hairy cell leukemia.
Blood 119:5332-5333(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29989027; DOI=10.18632/oncotarget.25601
Maitre E., Bertrand P., Maingonnat C., Viailly P.-J., Wiber M., Naguib D., Salaun V., Cornet E., Damaj G., Sola B., Jardin F., Troussard X.
New generation sequencing of targeted genes in the classical and the variant form of hairy cell leukemia highlights mutations in epigenetic regulation genes.
Oncotarget 9:28866-28876(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections (Providers) DSMZ; ACC-150
Cell line databases/resources CLO; CLO_0002014
CLDB; cl473
cancercelllines; CVCL_1090
Cell_Model_Passport; SIDM00984
Cosmic-CLP; 906695
DepMap; ACH-001452
DSMZCellDive; ACC-150
Biological sample resources BioSample; SAMN03473418
Chemistry resources PharmacoDB; BONNA12_106_2019
Encyclopedic resources Wikidata; Q54797948
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM1669627
Polymorphism and mutation databases Cosmic; 906695
Cosmic; 2690006
Cosmic; 2756295
IARC_TP53; 21196
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number30