ID   ARH-77
AC   CVCL_1072
SY   ARH 77; ARH77
DR   BTO; BTO_0002992
DR   CLO; CLO_0001744
DR   CLO; CLO_0001745
DR   EFO; EFO_0002111
DR   CLDB; cl285
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1621
DR   BCRC; 60385
DR   BioGRID_ORCS_Cell_line; 831
DR   BioSample; SAMN03471407
DR   CCRID; 4201HUM-CCTCC00218
DR   CCTCC; GDC0218
DR   Cell_Model_Passport; SIDM00900
DR   ChEMBL-Cells; CHEMBL3308536
DR   ChEMBL-Targets; CHEMBL2366241
DR   CLS; 300306
DR   Cosmic; 759914
DR   Cosmic; 886086
DR   Cosmic; 888020
DR   Cosmic; 906765
DR   Cosmic; 919148
DR   Cosmic; 999792
DR   Cosmic-CLP; 906765
DR   DepMap; ACH-002210
DR   DSMZ; ACC-512
DR   DSMZCellDive; ACC-512
DR   ECACC; 88121201
DR   EGA; EGAS00001000978
DR   FANTOM5_SSTAR; 10840-111E3
DR   GDSC; 906765
DR   GEO; GSM1374393
DR   GEO; GSM1669601
DR   IARC_TP53; 21176
DR   IGRhCellID; ARH77
DR   LINCS_LDP; LCL-2041
DR   Lonza; 593
DR   PharmacoDB; ARH77_64_2019
DR   PubChem_Cell_line; CVCL_1072
DR   Wikidata; Q54750440
RX   DOI=10.1007/0-306-46877-8_4;
RX   Patent=US4730036;
RX   PubMed=566614;
RX   PubMed=2140233;
RX   PubMed=2985879;
RX   PubMed=3159941;
RX   PubMed=3874327;
RX   PubMed=4042077;
RX   PubMed=6605913;
RX   PubMed=7140810;
RX   PubMed=7579375;
RX   PubMed=8051085;
RX   PubMed=9510473;
RX   PubMed=10516762;
RX   PubMed=10936422;
RX   PubMed=14555701;
RX   PubMed=18262052;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=20454443;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=30971826;
WW   Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/normal-morphology-for-atcc-crl-1621
CC   Problematic cell line: Misclassified. Originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line (PubMed=4042077; PubMed=7579375; PubMed=10516762).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Doubling time: 110.4 hours (PubMed=566614); ~30 hours (DSMZ=ACC-512).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (Cosmic-CLP=906765).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=2.24%; Native American=0.38%; East Asian, North=0%; East Asian, South=2.18%; South Asian=8.63%; European, North=25.32%; European, South=61.25% (PubMed=30894373).
CC   Misspelling: AHR 77; Note=Occasionally.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): ATCC=CRL-1621; CLS=300306; Cosmic-CLP=906765; DSMZ=ACC-512; ECACC=88121201
ST   Amelogenin: X
ST   CSF1PO: 6,10
ST   D12S391: 19,20
ST   D13S317: 11,13
ST   D16S539: 9,13
ST   D18S51: 14,16
ST   D19S433: 14,15
ST   D21S11: 29,30
ST   D2S1338: 17
ST   D3S1358: 16
ST   D5S818: 10,13
ST   D6S1043: 11,19
ST   D7S820: 7,12
ST   D8S1179: 14,15
ST   FGA: 20,21
ST   Penta D: 10
ST   Penta E: 12
ST   TH01: 8,9.3
ST   TPOX: 8
ST   vWA: 17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   33Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 43
CH   CVCL_A5YK ! ARH-77 clone A5P3
CH   CVCL_8119 ! HMy.2 B
//
RX   PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2;
RA   Drexler, Hans Gunther
RA   Matsuo, Yoshinobu
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   multiple myeloma and plasma cell leukemia.";
RL   Leuk. Res. 24:681-703(2000).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=4042077; DOI=10.1002/1097-0142(19851115)56:10<2544::AID-CNCR2820561039>3.0.CO;2-G;
RA   Ralph, Peter
RT   "The human B-cell lineage cell line ARH-77.";
RL   Cancer 56:2544-2545(1985).
//
RX   PubMed=18262052; DOI=10.1016/j.cancergencyto.2007.10.013;
RA   Parker, Helen
RA   Cheung, Kan Luk
RA   Robinson, Hazel M.
RA   Harrison, Christine Joyce
RA   Strefford, Jonathan C.
RT   "Cytogenetic and genomic characterization of cell line ARH77.";
RL   Cancer Genet. Cytogenet. 181:40-45(2008).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1.
RT   Carboxylic esterase.";
RL   Leuk. Res. 9:209-229(1985).
//
RX   DOI=10.1007/0-306-46877-8_4;
RA   Jernberg-Wiklund, Helena
RA   Nilsson, Kenneth
RT   "Multiple myeloma cell lines.";
RL   (In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000).
//
RX   PubMed=566614;
RA   Burk, Kenneth H.
RA   Drewinko, Benjamin
RA   Trujillo, Jose M.
RA   Ahearn, Michael John
RT   "Establishment of a human plasma cell line in vitro.";
RL   Cancer Res. 38:2508-2513(1978).
//
RX   PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x;
RA   Nakano, Akinobu
RA   Harada, Takayuki
RA   Morikawa, Shigeru
RA   Kato, Yuzuru
RT   "Expression of leukocyte common antigen (CD45) on various human
RT   leukemia/lymphoma cell lines.";
RL   Acta Pathol. Jpn. 40:107-115(1990).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=6605913; DOI=10.1016/0165-2478(83)90049-4;
RA   Ralph, Peter
RA   Saiki, Osamu
RA   Maurer, David H.
RA   Welte, Karl
RT   "IgM and IgG secretion in human B-cell lines regulated by
RT   B-cell-inducing factors (BIF) and phorbol ester.";
RL   Immunol. Lett. 7:17-23(1983).
//
RX   PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- III.
RT   Beta-hexosaminidase (E.C. 3.2.1.30).";
RL   Leuk. Res. 9:549-559(1985).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid
RT   phosphatase.";
RL   Leuk. Res. 9:537-548(1985).
//
RX   PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168;
RA   Uphoff, Cord C.
RA   Denkmann, Sabine A.
RA   Steube, Klaus G.
RA   Drexler, Hans Gunther
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
//
RX   PubMed=7579375; DOI=10.1182/blood.V86.10.4001.bloodjournal86104001;
RA   Pellat-Deceunynck, Catherine
RA   Amiot, Martine
RA   Bataille, Francois-Regis
RA   Van Riet, Ivan
RA   Van Camp, Benjamin
RA   Omede, Paola
RA   Boccadoro, Mario
RT   "Human myeloma cell lines as a tool for studying the biology of
RT   multiple myeloma: a reappraisal 18 years after.";
RL   Blood 86:4001-4002(1995).
//
RX   Patent=US4730036;
RA   Ralph, Peter
RA   Welte, Karl
RT   "Purifications of B-cell inducing factor (BIF) and B-cell growth
RT   factor (BGF).";
RL   Patent number US4730036, 08-Mar-1988.
//
RX   PubMed=14555701;
RA   Shammas, Masood A.
RA   Shmookler Reis, Robert Joseph
RA   Akiyama, Masaharu
RA   Koley, Hemanta
RA   Chauhan, Dharminder
RA   Hideshima, Teru
RA   Goyal, Raj K.
RA   Hurley, Laurence H.
RA   Anderson, Kenneth Carl
RA   Munshi, Nikhil C.
RT   "Telomerase inhibition and cell growth arrest by G-quadruplex
RT   interactive agent in multiple myeloma.";
RL   Mol. Cancer Ther. 2:825-833(2003).
//
RX   PubMed=10516762; DOI=10.1038/sj.leu.2401510;
RA   Drexler, Hans Gunther
RA   Dirks, Wilhelm Gerhard
RA   MacLeod, Roderick A.F.
RT   "False human hematopoietic cell lines: cross-contaminations and
RT   misinterpretations.";
RL   Leukemia 13:1601-1607(1999).
//
RX   PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588;
RA   Hosoya, Noriko
RA   Hangaishi, Akira
RA   Ogawa, Seishi
RA   Miyagawa, Kiyoshi
RA   Mitani, Kinuko
RA   Yazaki, Yoshio
RA   Hirai, Hisamaru
RT   "Frameshift mutations of the hMSH6 gene in human leukemia cell
RT   lines.";
RL   Jpn. J. Cancer Res. 89:33-39(1998).
//
RX   PubMed=7140810; DOI=10.1002/eji.1830120804;
RA   Edwards, Paul A.W.
RA   Smith, Carissa M.
RA   Neville, Alexander Munro
RA   O'Hare, Michael J.
RT   "A human-hybridoma system based on a fast-growing mutant of the ARH-77
RT   plasma cell leukemia-derived line.";
RL   Eur. J. Immunol. 12:641-648(1982).
//
RX   PubMed=8051085; DOI=10.1016/S0021-9258(17)32120-8;
RA   Liebersbach, Brian F.
RA   Sanderson, Ralph D.
RT   "Expression of syndecan-1 inhibits cell invasion into type I
RT   collagen.";
RL   J. Biol. Chem. 269:20013-20019(1994).
//