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Cellosaurus ALL-PO (CVCL_1069)

[Text version]
Cell line name ALL-PO
Synonyms ALLPO; AllPO
Accession CVCL_1069
Resource Identification Initiative To cite this cell line use: ALL-PO (RRID:CVCL_1069)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Deep quantitative proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 7135; AFF1 + HGNC; 7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4 (PubMed=14671638; PubMed=35354797).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.07
East Asian, North2.2
East Asian, South1.8
South Asian1.45
European, North52.99
European, South41.49
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged (NCIt: C80342)
B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) (ORDO: Orphanet_585918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 4M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ICLC

Markers:
AmelogeninX
CSF1PO10,11
D5S81811,12
D7S8209,11
D13S31711,12
D16S53913
D21S1129,30
TH016,7
TPOX8,9
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=9444945; DOI=10.1016/S0145-2126(97)00092-1
Gobbi A., Di Berardino C., Scanziani E., Garofalo A., Rivolta A., Fontana G., Rambaldi A., Giavazzi R., Biondi A.
A human acute lymphoblastic leukemia line with the T(4;11) translocation as a model of minimal residual disease in SCID mice.
Leuk. Res. 21:1107-1114(1997)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Drexler H.G., Quentmeier H., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ICLC; HTL01003
Cell line databases/resources CLO; CLO_0001705
CLDB; cl5399
cancercelllines; CVCL_1069
Cell_Model_Passport; SIDM00211
Cosmic-CLP; 910944
DepMap; ACH-002209
LINCS_LDP; LCL-1043
Chemistry resources ChEMBL-Cells; CHEMBL3308227
ChEMBL-Targets; CHEMBL2366294
GDSC; 910944
PharmacoDB; ALLPO_58_2019
PubChem_Cell_line; CVCL_1069
Encyclopedic resources Wikidata; Q54749226
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669596
GEO; GSM5137706
GEO; GSM5137750
Polymorphism and mutation databases Cosmic; 910944
IARC_TP53; 21173
Proteomic databases PRIDE; PXD023662
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number37