ID 8505C AC CVCL_1054 SY 8505c DR BTO; BTO_0005550 DR CLO; CLO_0001513 DR CLO; CLO_0050951 DR EFO; EFO_0022669 DR CLDB; cl135 DR CLDB; cl136 DR AddexBio; C0025002/19 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BCRJ; 0398 DR BioSample; SAMN01821611 DR BioSample; SAMN03470935 DR BioSample; SAMN03472518 DR BioSample; SAMN03473379 DR BioSample; SAMN10988556 DR cancercelllines; CVCL_1054 DR Cell_Model_Passport; SIDM00996 DR CGH-DB; 54-1 DR ChEMBL-Cells; CHEMBL3308353 DR ChEMBL-Targets; CHEMBL1075387 DR Cosmic; 889489 DR Cosmic; 891256 DR Cosmic; 922365 DR Cosmic; 924102 DR Cosmic; 1084283 DR Cosmic; 1132598 DR Cosmic; 1152114 DR Cosmic; 1162837 DR Cosmic; 1239959 DR Cosmic; 2036694 DR Cosmic; 2054105 DR Cosmic; 2613248 DR Cosmic-CLP; 924102 DR DepMap; ACH-001307 DR DSMZ; ACC-219 DR DSMZCellDive; ACC-219 DR ECACC; 94090184 DR EGA; EGAS00001000978 DR FANTOM5_SSTAR; 10437-106E5 DR GDSC; 924102 DR GEO; GSM886847 DR GEO; GSM887911 DR GEO; GSM1669574 DR IARC_TP53; 1305 DR JCRB; JCRB0826 DR LiGeA; CCLE_065 DR LINCS_LDP; LCL-1686 DR PharmacoDB; 8505C_31_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_1054 DR PubChem_Cell_line; CVCL_1054 DR RCB; RCB2103 DR TKG; TKG 0439 DR Wikidata; Q54605341 RX PubMed=1516062; RX PubMed=9247707; RX PubMed=9290701; RX PubMed=14522906; RX PubMed=15613457; RX PubMed=16924234; RX PubMed=17725429; RX PubMed=17804723; RX PubMed=18713817; RX PubMed=19087340; RX PubMed=20164919; RX PubMed=21566963; RX PubMed=21868764; RX PubMed=22460905; RX PubMed=23162534; RX PubMed=23833040; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30737244; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31395879; RX PubMed=31978347; RX PubMed=35839778; WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/other-bladder-cervical/8505c-xenograft-model/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: TCGA-110-CL cell line panel. CC Population: Japanese. CC Doubling time: 36 hours (PubMed=21566963); ~30-40 hours (DSMZ=ACC-219); ~1.5 days (Note=Lot 11252003) (JCRB=JCRB0826). CC HLA typing: A*02:01,26:01; B*39:01,51:01; C*07:02,15:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (PubMed=23833040; PubMed=30737244; Cosmic-CLP=924102; DepMap=ACH-001307). CC Sequence variation: Mutation; HGNC; HGNC:7773; NF2; Simple; p.Glu129Ter (c.385G>T); Zygosity=Homozygous (PubMed=30737244; Cosmic-CLP=924102; DepMap=ACH-001307). CC Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gly (c.742C>G); ClinVar=VCV000376652; Zygosity=Hemizygous (PubMed=1516062; PubMed=14522906; PubMed=21566963; PubMed=23162534; PubMed=30737244; Cosmic-CLP=924102; DepMap=ACH-001307). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.58%; Native American=0%; East Asian, North=84.79%; East Asian, South=11.83%; South Asian=0%; European, North=0%; European, South=2.8% (PubMed=30894373). CC Misspelling: 8509C; Cosmic=1132598. CC Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046. ST Source(s): Cosmic-CLP=924102; DSMZ=ACC-219; ECACC=94090184; JCRB=JCRB0826; PubMed=18713817; PubMed=21868764; PubMed=25877200; PubMed=30737244; RCB=RCB2103; TKG=TKG 0439 ST Amelogenin: X ST CSF1PO: 12,13 ST D13S317: 13 ST D16S539: 12 ST D18S51: 16 ST D19S433: 13,14 ST D21S11: 28,32.2 ST D2S1338: 17,24 ST D3S1358: 16,17 ST D5S818: 10,11 ST D7S820: 10 ST D8S1179: 10,13 ST FGA: 23 ST Penta D: 9,10 ST Penta E: 12,15 ST TH01: 6 (PubMed=25877200) ST TH01: 6,9 (Cosmic-CLP=924102; DSMZ=ACC-219; ECACC=94090184; JCRB=JCRB0826; PubMed=21868764; PubMed=30737244; RCB=RCB2103; TKG=TKG 0439) ST TPOX: 10,11 (Cosmic-CLP=924102; DSMZ=ACC-219; PubMed=30737244; RCB=RCB2103; TKG=TKG 0439) ST TPOX: 11 (ECACC=94090184; JCRB=JCRB0826; PubMed=21868764; PubMed=25877200) ST vWA: 17,19 DI NCIt; C3878; Thyroid gland anaplastic carcinoma DI ORDO; Orphanet_142; Anaplastic thyroid carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 78Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 49 // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=16924234; DOI=10.1038/sj.onc.1209899; RA Yu, Wei RA Imoto, Issei RA Inoue, Jun RA Onda, Masahiko RA Emi, Mitsuru RA Inazawa, Johji RT "A novel amplification target, DUSP26, promotes anaplastic thyroid RT cancer cell growth by inhibiting p38 MAPK activity."; RL Oncogene 26:1178-1187(2007). // RX PubMed=1516062; RA Yoshimoto, Katsuhiko RA Iwahana, Hiroyuki RA Fukuda, Ayumi RA Sano, Toshiaki RA Saito, Shiro RA Itakura, Mitsuo RT "Role of p53 mutations in endocrine tumorigenesis: mutation detection RT by polymerase chain reaction-single strand conformation RT polymorphism."; RL Cancer Res. 52:5061-5064(1992). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=19087340; DOI=10.1186/1471-2407-8-371; PMCID=PMC2651892; RA Ribeiro, Franclim Ricardo RA Meireles, Ana Margarida RA Rocha, Ana Sofia RA Teixeira, Manuel R. RT "Conventional and molecular cytogenetics of human non-medullary RT thyroid carcinoma: characterization of eight cell line models and RT review of the literature on clinical samples."; RL BMC Cancer 8:371.1-371.11(2008). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=14522906; RA Frasca, Francesco RA Vella, Veronica RA Aloisi, Alessandra RA Mandarino, Angelo RA Mazzon, Emanuela RA Vigneri, Riccardo RA Vigneri, Paolo RT "p73 tumor-suppressor activity is impaired in human thyroid cancer."; RL Cancer Res. 63:5829-5837(2003). // RX PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785; RA Yu, Katharine RA Chen, Bin RA Aran, Dvir RA Charalel, Joe RA Yau, Christina RA Wolf, Douglas M. RA van 't Veer, Laura J. RA Butte, Atul Janardhan RA Goldstein, Ted RA Sirota, Marina RT "Comprehensive transcriptomic analysis of cell lines as models of RT primary tumors across 22 tumor types."; RL Nat. Commun. 10:3574.1-3574.11(2019). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin K. RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569; RA Schweppe, Rebecca E. RA Klopper, Joshua P. RA Korch, Christopher T. RA Pugazhenthi, Umarani RA Benezra, Miriam RA Knauf, Jeffrey A. RA Fagin, James Alexander RA Marlow, Laura A. RA Copland, John Alton 3rd RA Smallridge, Robert Christian RA Haugen, Bryan R. RT "Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer RT cell lines reveals cross-contamination resulting in cell line RT redundancy and misidentification."; RL J. Clin. Endocrinol. Metab. 93:4331-4341(2008). // RX PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280; RA Landa, Inigo RA Pozdeyev, Nikita RA Korch, Christopher T. RA Marlow, Laura A. RA Smallridge, Robert Christian RA Copland, John Alton 3rd RA Henderson, Ying C. RA Lai, Stephen Y. RA Clayman, Gary L. RA Onoda, Naoyoshi RA Tan, Aik-Choon RA Garcia-Rendueles, Maria E.R. RA Knauf, Jeffrey A. RA Haugen, Bryan R. RA Fagin, James Alexander RA Schweppe, Rebecca E. RT "Comprehensive genetic characterization of human thyroid cancer cell RT lines: a validated panel for preclinical studies."; RL Clin. Cancer Res. 25:3141-3151(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662; RA Zhao, Mei RA Sano, Daisuke RA Pickering, Curtis R. RA Jasser, Samar A. RA Henderson, Ying C. RA Clayman, Gary L. RA Sturgis, Erich M. RA Ow, Thomas J. RA Lotan, Reuben RA Carey, Thomas E. RA Sacks, Peter G. RA Grandis, Jennifer Rubin RA Sidransky, David RA Heldin, Nils-Erik RA Myers, Jeffrey N. RT "Assembly and initial characterization of a panel of 85 genomically RT validated cell lines from diverse head and neck tumor sites."; RL Clin. 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RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=21566963; DOI=10.3892/ijo.4.3.583; RA Ito, Takashi RA Seyama, Toshio RA Hayashi, Yuzo RA Hayashi, Tomonori RA Dohi, Kiyohiko RA Mizuno, Terumi RA Iwamoto, Keisuke S. RA Tsuyama, Naohiro RA Nakamura, Nori RA Akiyama, Mitoshi RT "Establishment of 2 human thyroid-carcinoma cell-lines (8305C, 8505C) RT bearing p53 gene-mutations."; RL Int. J. Oncol. 4:583-586(1994). // RX PubMed=9247707; DOI=10.1080/15216549700202901; RA Hatakeyama, Setsuko RA Gao, Yu-Hao RA Ohara-Nemoto, Yuko RA Kataoka, Hiroaki RA Satoh, Masanobu RT "Expression of bone morphogenetic proteins of human neoplastic RT epithelial cells."; RL Biochem. Mol. Biol. Int. 42:497-505(1997). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026; RA van Staveren, Wilma C.G. RA Weiss-Solis, David Y. RA Delys, Laurent RA Duprez, Laurence RA Andry, Guy RA Franc, Brigitte RA Thomas, Gerry RA Libert, Frederick RA Dumont, Jacques-Emile RA Detours, Vincent RA Maenhaut, Carine RT "Human thyroid tumor cell lines derived from different tumor types RT present a common dedifferentiated phenotype."; RL Cancer Res. 67:8113-8120(2007). // RX PubMed=17725429; DOI=10.1089/thy.2007.0097; RA Meireles, Ana Margarida RA Preto, Ana RA Rocha, Ana Sofia RA Rebocho, Ana Paula RA Maximo, Valdemar RA Pereira-Castro, Isabel RA Moreira, Severina RA Feijao, Talia RA Botelho, Tiago RA Marques, Ricardo RA Trovisco, Vitor RA Cirnes, Luis RA Alves, Cintia RA Velho, Sergia RA Soares, Paula RA Sobrinho-Simoes, Manuel RT "Molecular and genotypic characterization of human thyroid follicular RT cell carcinoma-derived cell lines."; RL Thyroid 17:707-715(2007). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=23162534; DOI=10.3389/fendo.2012.00133; PMCID=PMC3499787; RA Saiselet, Manuel RA Floor, Sebastien RA Tarabichi, Maxime RA Dom, Genevieve RA Hebrant, Aline RA van Staveren, Wilma C.G. RA Maenhaut, Carine RT "Thyroid cancer cell lines: an overview."; RL Front. Endocrinol. 3:133.1-133.9(2012). // RX PubMed=15613457; DOI=10.1677/erc.1.00818; RA Onda, Masahiko RA Emi, Mitsuru RA Yoshida, Akira RA Miyamoto, S. 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