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Cellosaurus NALM-6/SP-B (CVCL_0U51)

[Text version]
Cell line name NALM-6/SP-B
Accession CVCL_0U51
Resource Identification Initiative To cite this cell line use: NALM-6/SP-B (RRID:CVCL_0U51)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90235; Spiruchostatin B (SP-B).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0092 (NALM-6)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=22684370; DOI=10.3892/ijo.2012.1507; PMCID=PMC3582725
Kanno S.-i., Maeda N., Tomizawa A., Yomogida S., Katoh T., Ishikawa M.
Characterization of cells resistant to the potent histone deacetylase inhibitor spiruchostatin B (SP-B) and effect of overexpressed p21waf1/cip1 on the SP-B resistance or susceptibility of human leukemia cells.
Int. J. Oncol. 41:862-868(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0U51
Encyclopedic resources Wikidata; Q54907438
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number16