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Cellosaurus 12Z (CVCL_0Q73)

[Text version]
Cell line name 12Z
Synonyms 12z; 12-Z; Z12; Z-12; Z12 Eo; EEC12Z
Accession CVCL_0Q73
Resource Identification Initiative To cite this cell line use: 12Z (RRID:CVCL_0Q73)
Comments Doubling time: 31 hours (PubMed=11696444).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Endometrium, epithelium; UBERON=UBERON_0004811.
Cell type: Epithelial cell; CL=CL_0000066.
Disease Endometriosis (NCIt: C3014)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UT50 (12Z-GFP)
Sex of cell Female
Age at sampling 37Y
Category Transformed cell line
STR profile Source(s): PubMed=32106286

Markers:
AmelogeninX
CSF1PO11,13
D2S133819
D3S135814,17
D5S81812
D7S8209,12
D8S117910
D13S31712,13
D16S53913
D18S5113,15
D19S43313,14
D21S1128,30.2
FGA23,24
TH019,9.3
TPOX11,12
vWA17

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Publications

PubMed=11696444; DOI=10.1016/S0002-9440(10)63030-1; PMCID=PMC1867070
Zeitvogel A., Baumann R., Starzinski-Powitz A.
Identification of an invasive, N-cadherin-expressing epithelial cell type in endometriosis using a new cell culture model.
Am. J. Pathol. 159:1839-1852(2001)

PubMed=18001719; DOI=10.1016/j.fertnstert.2007.07.1358
Banu S.K., Lee J., Starzinski-Powitz A., Arosh J.A.
Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells.
Fertil. Steril. 90:972-987(2008)

PubMed=24502583; DOI=10.1186/1757-2215-7-17; PMCID=PMC4015880
Brueggmann D., Templeman C., Starzinski-Powitz A., Rao N.P., Gayther S.A., Lawrenson K.
Novel three-dimensional in vitro models of ovarian endometriosis.
J. Ovarian Res. 7:17.1-17.11(2014)

PubMed=26199416; DOI=10.1073/pnas.1507931112; PMCID=PMC4534219
Arosh J.A., Lee J., Balasubbramanian D., Stanley J.A., Long C.R., Meagher M.W., Osteen K.G., Bruner-Tran K.L., Burghardt R.C., Starzinski-Powitz A., Banu S.K.
Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis.
Proc. Natl. Acad. Sci. U.S.A. 112:9716-9721(2015)

PubMed=32106286; DOI=10.1093/humrep/dez266; PMCID=PMC7048714
Romano A., Xanthoulea S., Giacomini E., Delvoux B., Alleva E., Vigano P.
Endometriotic cell culture contamination and authenticity: a source of bias in in vitro research?
Hum. Reprod. 35:364-376(2020)

Cross-references
Cell line collections (Providers) ABM; T0764
Millipore; SCC443
Anatomy/cell type resources BTO; BTO_0005656
Encyclopedic resources Wikidata; Q54581361
Polymorphism and mutation databases Cosmic; 1432838
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number18