ID   MP-CCS-SY
AC   CVCL_0J33
SY   Miyazaki Pediatrics-Clear cell Sarcoma-SY
DR   EGA; EGAD00001008611
DR   Wikidata; Q28726672
RX   CelloPub=CLPUB00599;
RX   PubMed=12072203;
RX   PubMed=28745431;
RX   PubMed=36959380;
CC   Population: Japanese.
CC   Doubling time: 36 hours (PubMed=12072203).
CC   Sequence variation: Gene fusion; HGNC; HGNC:783; ATF1 + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-ATF1, EWS-ATF; Note=Type 1: EWSR1 exon 8 fused to ATF1 exon 4 (PubMed=12072203; PubMed=28745431).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Bone, left femur; UBERON=UBERON_0000981.
ST   Source(s): PubMed=36959380
ST   Amelogenin: X
ST   CSF1PO: 9,12
ST   D13S317: 11,12
ST   D16S539: 9,11
ST   D18S51: 14,25
ST   D21S11: 30,32.2
ST   D3S1358: 17
ST   D5S818: 9,12
ST   D7S820: 8,13
ST   D8S1179: 13,14
ST   FGA: 20,22
ST   Penta D: 9,11
ST   Penta E: 11,12
ST   TH01: 7,9.3
ST   TPOX: 8,11
ST   vWA: 14
DI   NCIt; C3745; Clear cell sarcoma of soft tissue
DI   ORDO; Orphanet_3394; Soft tissue sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   17-18Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 19-12-24; Version: 13
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RX   CelloPub=CLPUB00599;
RA   Sugimoto T., Kuroda H., Kuwahara Y., Katsumi Y., Misawa A.,
RA   Moritake H., Hosoi H.;
RT   "Cellular and molecular characteristics of established childhood
RT   soft-tissue sarcoma cell lines.";
RL   J. Cancer Res. Therap. Oncol. 7:202.1-202.12(2019).
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RX   PubMed=12072203; DOI=10.1016/S0165-4608(01)00641-0;
RA   Moritake H., Sugimoto T., Asada Y., Yoshida M.A., Maehara Y.,
RA   Epstein A.L., Kuroda H.;
RT   "Newly established clear cell sarcoma (malignant melanoma of soft
RT   parts) cell line expressing melanoma-associated Melan-A antigen and
RT   overexpressing C-MYC oncogene.";
RL   Cancer Genet. Cytogenet. 135:48-56(2002).
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RX   PubMed=28745431; DOI=10.1002/cam4.1130; PMCID=PMC5603837;
RA   Nakai T., Imura Y., Tamiya H., Yamada S., Nakai S., Yasuda N., Kaneko K.,
RA   Outani H., Takenaka S., Hamada K., Myoui A., Araki N., Ueda T., Itoh K.,
RA   Yoshikawa H., Naka N.;
RT   "Trabectedin is a promising antitumor agent potentially inducing
RT   melanocytic differentiation for clear cell sarcoma.";
RL   Cancer Med. 6:2121-2130(2017).
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RX   PubMed=36959380; DOI=10.1038/s41416-023-02222-0; PMCID=PMC10147623;
RA   Rasmussen S.V., Wozniak A., Lathara M., Goldenberg J.M., Samudio B.M.,
RA   Bickford L.R., Nagamori K., Wright H., Woods A.D., Chauhan S., Lee C.-J.,
RA   Rudzinski E.R., Swift M.K., Kondo T., Fisher D.E., Imyanitov E.N.,
RA   Machado I., Llombart-Bosch A., Andrulis I.L., Gokgoz N., Wunder J.S.,
RA   Moritake H., Nakamura T., Srinivasa G., Thway K., Jones R.L., Huang P.H.,
RA   Berlow N.E., Schoffski P., Keller C.;
RT   "Functional genomics of human clear cell sarcoma: genomic,
RT   transcriptomic and chemical biology landscape for clear cell sarcoma.";
RL   Br. J. Cancer 128:1941-1954(2023).
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