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Cellosaurus T47D/A1-2 (CVCL_0I95)

[Text version]
Cell line name T47D/A1-2
Synonyms T47D(A1-2); T47D A1-2; A1-2
Accession CVCL_0I95
Resource Identification Initiative To cite this cell line use: T47D/A1-2 (RRID:CVCL_0I95)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=RGD; 2741; Nr3c1.
Omics: Transcriptome analysis by RNAseq.
Omics: Transcriptome analysis by single cell RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0553 (T-47D)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=2550815; DOI=10.1210/mend-3-8-1270
Nordeen S.K., Kuhnel B., Lawler-Heavner J., Barber D.A., Edwards D.P.
A quantitative comparison of dual control of a hormone response element by progestins and glucocorticoids in the same cell line.
Mol. Endocrinol. 3:1270-1278(1989)

PubMed=32170217; DOI=10.1038/s42003-020-0837-0; PMCID=PMC7070043
Hoffman J.A., Papas B.N., Trotter K.W., Archer T.K.
Single-cell RNA sequencing reveals a heterogeneous response to glucocorticoids in breast cancer cells.
Commun. Biol. 3:126.1-126.11(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0I95
Encyclopedic resources Wikidata; Q54971573
Gene expression databases GEO; GSE141834
Entry history
Entry creation10-Apr-2015
Last entry update10-Sep-2024
Version number14