| Cell line name |
S1-B1-20 |
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| Synonyms |
S1B1-20; S1B20 |
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| Accession |
CVCL_0H85 |
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| Resource Identification Initiative |
To cite this cell line use: S1-B1-20 (RRID:CVCL_0H85) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:88337; Bisantrene.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0H88 (S1) |
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| Sex of cell |
Female |
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| Age at sampling |
58Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=7865904
Zhang X.P., Ritke M.K., Yalowich J.C., Slovak M.L., Ho J.P., Collins K.I., Annable T., Arceci R.J., Durr F.E., Greenberger L.M.
P-glycoprotein mediates profound resistance to bisantrene.
Oncol. Res. 6:291-301(1994) PubMed=9865745
Rabindran S.K., He H.-Y., Singh M., Brown E., Collins K.I., Annable T., Greenberger L.M.
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.
Cancer Res. 58:5850-5858(1998) PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_0H85
|
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| Chemistry resources |
ChEMBL-Cells; CHEMBL3307291
ChEMBL-Targets; CHEMBL614053
PubChem_Cell_line; CVCL_0H85
|
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| Encyclopedic resources |
Wikidata; Q54951788
|
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| Entry history |
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| Entry creation | 10-Apr-2015 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 15 |
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