| Cell line name |
JPX-9 |
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| Synonyms |
Jpx-9; JPX9; JPX 9-4 |
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| Accession |
CVCL_0D86 |
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| Resource Identification Initiative |
To cite this cell line use: JPX-9 (RRID:CVCL_0D86) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03409; Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) tax.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0065 (Jurkat) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=2501514; DOI=10.1128/JVI.63.8.3220-3226.1989; PMCID=PMC250891
Nagata K., Ohtani K., Nakamura M., Sugamura K.
Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat.
J. Virol. 63:3220-3226(1989) PubMed=2784206; DOI=10.1093/nar/17.4.1589; PMCID=PMC331824
Ohtani K., Nakamura M., Saito S., Nagata K., Sugamura K., Hinuma Y.
Electroporation: application to human lymphoid cell lines for stable introduction of a transactivator gene of human T-cell leukemia virus type I.
Nucleic Acids Res. 17:1589-1604(1989) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_0D86
|
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| Encyclopedic resources |
Wikidata; Q54899053
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| Entry history |
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| Entry creation | 10-Apr-2015 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 17 |
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