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Cellosaurus HCC-3 (CVCL_0C57)

[Text version]
Cell line name HCC-3
Synonyms HCC.3; HCC3; AKH13
Accession CVCL_0C57
Secondary accession CVCL_0C55
Resource Identification Initiative To cite this cell line use: HCC-3 (RRID:CVCL_0C57)
Comments Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; miRNA profiling; Microarray.
Miscellaneous: Direct author submission of STR profile from Rohr-Udilova N.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Unspecified (PubMed=31063779).
Disease Hepatitis C infection (NCIt: C3098)
Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0C49 ! MF-3
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135817,18
D5S81813
D7S82011
D8S117914,15
D13S3179,12
D16S53912
D18S5114,17
D21S1129
FGA20
Penta D9
Penta E7,13
TH017
TPOX11
vWA14,17

Run an STR similarity search on this cell line
Web pages Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/HCC.3
Publications

PubMed=16809312; DOI=10.1128/JVI.00020-06; PMCID=PMC1489065
Metzl C., Mischek D., Salmons B., Gunzburg W.H., Renner M., Portsmouth D.
Tissue- and tumor-specific targeting of murine leukemia virus-based replication-competent retroviral vectors.
J. Virol. 80:7070-7078(2006)

PubMed=18594539; DOI=10.1038/sj.bjc.6604440; PMCID=PMC2453035
Sagmeister S., Eisenbauer M., Pirker C., Mohr T., Holzmann K., Zwickl H., Bichler C., Kandioler-Eckersberger D., Wrba F., Mikulits W., Gerner C., Shehata M., Majdic O., Streubel B., Berger W., Micksche M., Zatloukal K., Schulte-Hermann R., Grasl-Kraupp B.
New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis.
Br. J. Cancer 99:151-159(2008)

PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665
Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Caruso S., Calatayud A.-L., Pilet J., La Bella T., Rekik S., Imbeaud S., Letouze E., Meunier L., Bayard Q., Rohr-Udilova N., Peneau C., Grasl-Kraupp B., de Koning L., Ouine B., Bioulac-Sage P., Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0C57
TOKU-E; 3990
Encyclopedic resources Wikidata; Q54749093
Polymorphism and mutation databases Cosmic; 1628384
Cosmic; 2162535
Entry history
Entry creation10-Apr-2015
Last entry update10-Apr-2025
Version number12