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Cellosaurus HROC18 (CVCL_0B45)

[Text version]
Cell line name HROC18
Synonyms HROC 18
Accession CVCL_0B45
Resource Identification Initiative To cite this cell line use: HROC18 (RRID:CVCL_0B45)
Comments From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
Population: Caucasian.
Doubling time: 35 +- 7.2 hours (PubMed=25574089).
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Cecum; UBERON=UBERON_0001153.
HLA typing Source: CLS=300808
Class I
HLA-AA*01:01:01,02:01:01
HLA-BB*08:01:01,15:24:01
HLA-CC*07:01:01
Class II
HLA-DPDPB1*01:01,04:01
HLA-DQDQA1*05:01:01,05:05:01
DQB1*02:01:01,03:01:01
HLA-DRDRB1*03:01:01,13:03:01
Disease Cecum adenocarcinoma (NCIt: C5543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C0UD ! B-LCL-HROC18
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): CLS=300808; Direct_author_submission; PubMed=25926053

Markers:
AmelogeninX
CSF1PO12
D5S8189,11
D7S8208,11
D13S31711
D16S53912,13
D21S1130,33.2
TH017,8
TPOX8
vWA17

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Publications

PubMed=24647592; DOI=10.3892/or.2014.3097
Huhns M., Salem T., Schneider B., Krohn M., Linnebacher M., Prall F.
PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: two hits on the gene?
Oncol. Rep. 31:2236-2244(2014)

PubMed=25309914; DOI=10.1155/2014/568693; PMCID=PMC4182691
Lange F., Franz B., Maletzki C., Linnebacher M., Huhns M., Jaster R.
Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
BioMed Res. Int. 2014:568693.1-568693.13(2014)

PubMed=25574089; DOI=10.3748/wjg.v21.i1.164; PMCID=PMC4284332
Maletzki C., Gock M., Randow M., Klar E., Huhns M., Prall F., Linnebacher M.
Establishment and characterization of cell lines from chromosomal instable colorectal cancer.
World J. Gastroenterol. 21:164-176(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890
Mullins C.S., Micheel B., Matschos S., Leuchter M., Burtin F., Krohn M., Huhns M., Klar E., Prall F., Linnebacher M.
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references
Cell line collections (Providers) CLS; 300808
Encyclopedic resources Wikidata; Q54895248
Gene expression databases GEO; GSM1448095
Polymorphism and mutation databases Cosmic; 2151360
Cosmic; 2324288
Entry history
Entry creation10-Apr-2015
Last entry update10-Apr-2025
Version number20