Cellosaurus cell line RPK-59 (CVCL

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Cross-references
Cell line name	RPK-59
Synonyms	RPK59
Accession	CVCL_0B32
Resource Identification Initiative	To cite this cell line use: RPK-59 (RRID:CVCL_0B32)
Comments	Population: Japanese. Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar). Omics: Transcriptome analysis by microarray. Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations	Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=22490663).
Disease	Pancreatic carcinoma (NCIt: C207229)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_4897 (PK-59)
Sex of cell	Female
Age at sampling	66Y
Category	Cancer cell line
Publications	PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122 Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M., Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S., Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M., Ishida M., Motoi F., Egawa S., Unno M., Horii A. DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells. Biochem. Biophys. Res. Commun. 421:98-104(2012)
Cell line databases/resources	cancercelllines; CVCL_0B32
Anatomy/cell type resources	BTO; BTO:0005471
Encyclopedic resources	Wikidata; Q54951155
Gene expression databases	GEO; GSM862573 GEO; GSM862575
Entry history
Entry creation	10-Apr-2015
Last entry update	10-Sep-2024
Version number	13