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Cellosaurus Hs 888.T (CVCL_0979)

[Text version]
Cell line name Hs 888.T
Synonyms Hs-888-T; Hs888T; HS888T
Accession CVCL_0979
Resource Identification Initiative To cite this cell line use: Hs 888.T (RRID:CVCL_0979)
Comments Problematic cell line: Misclassified. Originally thought to be a osteosarcoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.69
East Asian, North0.26
East Asian, South1.64
South Asian7.7
European, North29.88
European, South57.38
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0977 ! Hs 888.Lu
CVCL_0978 ! Hs 888.Sk
CVCL_0987 ! Hs 894(A).T
CVCL_0988 ! Hs 894(B).T
CVCL_0989 ! Hs 894(C).T
CVCL_0990 ! Hs 894(D).T
CVCL_0991 ! Hs 894(E).Lu
CVCL_0996 ! Hs 899(A).T
CVCL_0997 ! Hs 899(B).T
CVCL_0998 ! Hs 899(C).T
CVCL_0999 ! Hs 899(D).T
Sex of cell Male
Age at sampling 20Y
Category Undefined cell line type
STR profile Source(s): ATCC


Run an STR similarity search on this cell line

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections (Providers) ATCC; CRL-7622
Cell line databases/resources CLO; CLO_0004186
cancercelllines; CVCL_0979
Cell_Model_Passport; SIDM01746
DepMap; ACH-000154
Biological sample resources BioSample; SAMN10988554
Chemistry resources PharmacoDB; Hs888_T_606_2019
Encyclopedic resources Wikidata; Q54896167
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887126
GEO; GSM888197
Polymorphism and mutation databases IARC_TP53; 30071
LiGeA; CCLE_713
Progenetix; CVCL_0979
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23