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Cellosaurus Hs 822.T (CVCL_0933)

[Text version]
Cell line name Hs 822.T
Synonyms Hs-822-T; Hs822T; HS822T
Accession CVCL_0933
Resource Identification Initiative To cite this cell line use: Hs 822.T (RRID:CVCL_0933)
Comments Problematic cell line: Misclassified. Originally thought to be a Ewing sarcoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap=ACH-000229).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone; UBERON=UBERON_0002481.
Cell type: Fibroblast; CL=CL_0000057.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.59
Native American21.59
East Asian, North1.66
East Asian, South0
South Asian2.06
European, North43.77
European, South30.33
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_S073 ! Hs 822.Sk
Sex of cell Female
Age at sampling 9Y
Category Undefined cell line type
STR profile Source(s): ATCC=CRL-7556

Markers:
AmelogeninX
CSF1PO12
D2S133820,23
D3S135814,18
D5S81811
D7S82010,11
D8S117912,15
D13S31712,13
D16S53911,13
D18S5115,18
D19S43313,15
D21S1132.2
FGA20
Penta D11,13
Penta E10,12
TH019,9.3
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

DOI=10.1101/166199
de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-7556
Cell line databases/resources CLO; CLO_0004140
cancercelllines; CVCL_0933
Cell_Model_Passport; SIDM01697
DepMap; ACH-000229
Biological sample resources BioSample; SAMN03471244
BioSample; SAMN10988161
Chemistry resources PharmacoDB; Hs822_T_599_2019
Encyclopedic resources Wikidata; Q54896089
Gene expression databases GEO; GSM887120
GEO; GSM888191
Polymorphism and mutation databases IARC_TP53; 30065
LiGeA; CCLE_706
Progenetix; CVCL_0933
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number22