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Cellosaurus Hs 688(A).T (CVCL_0846)

[Text version]
Cell line name Hs 688(A).T
Synonyms Hs688(A)T; Hs-688A-T; HS688AT
Accession CVCL_0846
Resource Identification Initiative To cite this cell line use: Hs 688(A).T (RRID:CVCL_0846)
Comments Problematic cell line: Misclassified. Originally thought to be a melanoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap=ACH-000306).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North0.14
East Asian, South0
South Asian2.86
European, North65.65
European, South31.35
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0847 ! Hs 688(B).T
Sex of cell Male
Age at sampling 69Y
Category Undefined cell line type
STR profile Source(s): ATCC=CRL-7425

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133818,20
D3S135816,17
D5S8188,11
D7S82010,11
D8S117912,13
D13S31712,13
D16S5399,13
D18S5119
D19S43312
D21S1128,31.2
FGA23,26
Penta D12,14
Penta E5,10
TH017,9
TPOX8,11
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

DOI=10.1101/166199
de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-7425
Cell line databases/resources CLO; CLO_0004048
cancercelllines; CVCL_0846
Cell_Model_Passport; SIDM01563
DepMap; ACH-000306
Biological sample resources BioSample; SAMN03471496
BioSample; SAMN10988159
Chemistry resources PharmacoDB; Hs688_A_T_585_2019
Encyclopedic resources Wikidata; Q54895887
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887107
GEO; GSM888178
Polymorphism and mutation databases IARC_TP53; 30056
LiGeA; CCLE_203
Progenetix; CVCL_0846
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number23