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Cellosaurus Hs 600.T (CVCL_0814)

[Text version]
Cell line name Hs 600.T
Synonyms Hs-600-T; Hs600T; HS600T
Accession CVCL_0814
Resource Identification Initiative To cite this cell line use: Hs 600.T (RRID:CVCL_0814)
Comments Problematic cell line: Misclassified. Originally thought to be a melanoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap=ACH-000240).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American1.98
East Asian, North1.7
East Asian, South0
South Asian0
European, North65.3
European, South31.02
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_G019 ! Hs 600.Sk
Sex of cell Male
Age at sampling Age unspecified
Category Undefined cell line type
STR profile Source(s): ATCC=CRL-7360

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133823,25
D3S135815
D5S81811,12
D7S8208,9
D8S117913,14
D13S31711
D16S53911,12
D18S5113,18
D19S43315,15.2
D21S1130,31.2
FGA20.2,22
Penta D9,10
Penta E5,7
TH017,9.3
TPOX8
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

DOI=10.1101/166199
de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-7360
Cell line databases/resources CLO; CLO_0004016
cancercelllines; CVCL_0814
Cell_Model_Passport; SIDM01580
DepMap; ACH-000240
Biological sample resources BioSample; SAMN03471483
BioSample; SAMN10988168
Chemistry resources PharmacoDB; Hs600_T_577_2019
Encyclopedic resources Wikidata; Q54895800
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM827397
GEO; GSM887099
GEO; GSM888170
Polymorphism and mutation databases IARC_TP53; 30049
LiGeA; CCLE_894
Progenetix; CVCL_0814
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number24