Cellosaurus cell line Hs 578Bst (CVCL

Cellosaurus Hs 578Bst (CVCL_0807)

[Text version]

Cell line name

Hs 578Bst

Synonyms

Hs578Bst; HS578BST; Hs-578Bst; Hs 578.Bst; Homo sapiens No. 578, breast cells

Accession

CVCL_0807

Resource Identification Initiative

To cite this cell line use: Hs 578Bst (RRID:CVCL_0807)

Comments

Part of: ICBP43 breast cancer cell line panel.
Population: Caucasian.
Omics: Mitochondrial genome sequenced.
Caution: Although it is part of a cancer cell line panel, it is a normal fibroblastic epithelial/myoepithelial cell line.
Misspelling: Hs57Bst; DOI=10.1016/B978-0-12-333530-2.50009-5.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.

Sequence variations

Mutation; HGNC; HGNC:7427; MT-CYB; Simple; p.Ala125Thr (m.15119G>A); ClinVar=VCV000693829; Zygosity=Heteroplasmic; Note=Less <1% while homoplasmic in autologous cell line Hs 578T (PubMed=29671673).

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_S253 ! Hs 578.Mg
CVCL_0332 ! Hs 578T

Sex of cell

Female

Age at sampling

74Y

Category

Finite cell line

STR profile

Source(s): ATCC=HTB-125

Markers:

Amelogenin	X
CSF1PO	11,13
D2S1338	17,26
D3S1358	16,17
D5S818	11,13
D7S820	10
D8S1179	13
D13S317	11,13
D16S539	9,12
D18S51	16
D19S433	14,15
D21S11	29,32.2
FGA	23,24
Penta D	8,13
Penta E	13,14
TH01	9,9.3
TPOX	8
vWA	17

Web pages

https://lincs.hms.harvard.edu/resources/reagents/icbp43/

Publications

PubMed=864756; DOI=10.1093/jnci/58.6.1795
Hackett A.J., Smith H.S., Springer E.L., Owens R.B., Nelson-Rees W.A., Riggs J.L., Gardner M.B.
Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines.
J. Natl. Cancer Inst. 58:1795-1806(1977)

DOI=10.1016/B978-0-12-333530-2.50009-5
Leibovitz A.
Cell lines from human breast.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York; USA (1994)

PubMed=29671673; DOI=10.1080/24701394.2018.1461852
Hedberg A., Knutsen E., Lovhaugen A.S., Jorgensen T.E., Perander M., Johansen S.D.
Cancer-specific SNPs originate from low-level heteroplasmic variants in human mitochondrial genomes of a matched cell line pair.
Mitochondrial DNA A. DNA Mapp. Seq. Anal. 30:82-91(2019)

Cross-references

Cell line collections (Providers)

ATCC; HTB-125
IZSLER; BS CL 190

Cell line databases/resources

CLO; CLO_0004008
CLDB; cl1715
CCRID; 3101HUMGNHu16

Anatomy/cell type resources

BTO; BTO_0003886

Biological sample resources

BioSample; SAMN03471102

Chemistry resources

PharmacoDB; HS578BST_617_2019

Encyclopedic resources