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Cellosaurus WRO (CVCL_0582)

[Text version]
Cell line name WRO
Synonyms WRO82-1; WRO 82-1; WRO-82; WRO82; UCLA RO 82-W-1; UCLA RO-82W-1; UCLA RO82W1; RO82W1; RO 82 W-1; RO82-W-1; RO82W-1; RO82
Accession CVCL_0582
Secondary accession CVCL_1663
Resource Identification Initiative To cite this cell line use: WRO (RRID:CVCL_0582)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: 4 days (PubMed=2570483).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Mitochondrial genome sequenced.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Not specified.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.33
Native American0
East Asian, North1.32
East Asian, South3.34
South Asian7.27
European, North24
European, South61.74
Disease Thyroid gland follicular carcinoma (NCIt: C8054)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=930083; DepMap=ACH-001384; ICLC=HTL98002

Markers:
AmelogeninX
CSF1PO10,11
D3S135814,15
D5S81812
D7S8208,12
D8S117911,16
D13S3179
D16S53911,12 (DepMap=ACH-001384; ICLC=HTL98002)
12 (Cosmic-CLP=930083)
D18S5110,13
D21S1129
FGA22.2,23
Penta D10
Penta E19,20
TH017,9.3
TPOX8
vWA16,19 (Cosmic-CLP=930083; DepMap=ACH-001384)
16,21 (ICLC=HTL98002)

Run an STR similarity search on this cell line
Publications

PubMed=2551628; DOI=10.1210/endo-125-4-1783
Pang X.-P., Hershman J.M., Chung M., Pekary A.E.
Characterization of tumor necrosis factor-alpha receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin.
Endocrinology 125:1783-1788(1989)

PubMed=2570483; DOI=10.1007/BF02899078
Estour B., Van Herle A.J., Juillard G.J.-F., Totanes T.L., Sparkes R.S., Giuliano A.E., Klandorf H.
Characterization of a human follicular thyroid carcinoma cell line (UCLA RO 82 W-1).
Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 57:167-174(1989)

PubMed=8423216; DOI=10.1172/JCI116168; PMCID=PMC330012
Fagin J.A., Matsuo K., Karmakar A., Chen D.-L., Tang S.-H., Koeffler H.P.
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.
J. Clin. Invest. 91:179-184(1993)

PubMed=9348181; DOI=10.1210/endo.138.11.5509
Nishihara E., Nagayama Y., Mawatari F., Tanaka K., Namba H., Niwa M., Yamashita S.
Retrovirus-mediated herpes simplex virus thymidine kinase gene transduction renders human thyroid carcinoma cell lines sensitive to ganciclovir and radiation in vitro and in vivo.
Endocrinology 138:4577-4583(1997)

PubMed=11439348; DOI=10.1038/sj.onc.1204531
Frasca F., Vigneri P., Vella V., Vigneri R., Wang J.Y.-J.
Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor.
Oncogene 20:3845-3856(2001)

PubMed=14522906
Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R., Vigneri P.
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=16778181; DOI=10.1158/0008-5472.CAN-06-0171
Bonora E., Porcelli A.M., Gasparre G., Biondi A., Ghelli A., Carelli V., Baracca A., Tallini G., Martinuzzi A., Lenaz G., Rugolo M., Romeo G.
Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.
Cancer Res. 66:6087-6096(2006)

PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026
van Staveren W.C.G., Weiss-Solis D.Y., Delys L., Duprez L., Andry G., Franc B., Thomas G., Libert F., Dumont J.-E., Detours V., Maenhaut C.
Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
Cancer Res. 67:8113-8120(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569
Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. 3rd, Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23162534; DOI=10.3389/fendo.2012.00133; PMCID=PMC3499787
Saiselet M., Floor S., Tarabichi M., Dom G., Hebrant A., van Staveren W.C.G., Maenhaut C.
Thyroid cancer cell lines: an overview.
Front. Endocrinol. 3:133.1-133.9(2012)

PubMed=25675381; DOI=10.1210/jc.2014-2764; PMCID=PMC4422887
von Roemeling C.A., Marlow L.A., Pinkerton A.B., Crist A., Miller J., Tun H.W., Smallridge R.C., Copland J.A. 3rd
Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.
J. Clin. Endocrinol. Metab. 100:E697-E709(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ECACC; 92030502
ICLC; HTL98002
Cell line databases/resources CLO; CLO_0008860
MCCL; MCC:0000488
CLDB; cl4167
CLDB; cl4902
cancercelllines; CVCL_0582
Cell_Model_Passport; SIDM00218
Cosmic-CLP; 930083
DepMap; ACH-001384
LINCS_LDP; LCL-1680
Lonza; 1209
TOKU-E; 4066
Anatomy/cell type resources BTO; BTO_0004772
Chemistry resources ChEMBL-Cells; CHEMBL3308779
ChEMBL-Targets; CHEMBL1075565
GDSC; 930083
PharmacoDB; RO82W1_1322_2019
PubChem_Cell_line; CVCL_0582
Encyclopedic resources Wikidata; Q54994417
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827437
GEO; GSM1670384
Polymorphism and mutation databases Cosmic; 684194
Cosmic; 685606
Cosmic; 849971
Cosmic; 886554
Cosmic; 918181
Cosmic; 928830
Cosmic; 930083
Cosmic; 931244
Cosmic; 990535
Cosmic; 1005459
Cosmic; 1094762
Cosmic; 1152113
Cosmic; 1155332
Cosmic; 1161614
Cosmic; 1162842
Cosmic; 1280051
Cosmic; 1699415
Cosmic; 2319849
IARC_TP53; 2130
IARC_TP53; 27230
Progenetix; CVCL_0582
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number39