ID   WRL 68
AC   CVCL_0581
AS   CVCL_D685
SY   WRL-68; WRL68
DR   BTO; BTO:0002584
DR   CLO; CLO_0009633
DR   MCCL; MCC:0000487
DR   CLDB; cl4730
DR   ATCC; CL-48
DR   BCRC; 60338
DR   BioSample; SAMN03151767
DR   ChEMBL-Cells; CHEMBL3307993
DR   ChEMBL-Targets; CHEMBL612587
DR   ECACC; 89121403
DR   PubChem_Cell_line; CVCL_0581
DR   Wikidata; Q54994415
RX   Patent=CA999546A;
RX   Patent=US3935066;
RX   PubMed=7522099;
RX   PubMed=8389256;
RX   PubMed=20143388;
CC   Group: Patented cell line.
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=20143388). Originally thought to be a hepatic fetal epithelial cell line.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00351.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-48.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Misspelling: CL-48; Note=Based on the ATCC catalog number.
CC   Discontinued: BCRC; 60338; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): ATCC; ECACC
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 12,13.3 (ATCC)
ST   D13S317: 12,14 (ECACC)
ST   D16S539: 9,10
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 27
RX   Patent=CA999546A;
RA   Apostolov K.;
RT   "Human liver cell line.";
RL   Patent number CA999546A, 09-Nov-1976.
RX   Patent=US3935066;
RA   Apostolov K.;
RT   "Cell lines.";
RL   Patent number US3935066, 27-Jan-1976.
RX   PubMed=7522099; DOI=10.1007/BF02634356;
RA   Gutierrez-Ruiz M.C., Bucio Ortiz L., Souza V., Gomez J.J., Campos C.,
RA   Carabez-Trejo A.;
RT   "Expression of some hepatocyte-like functional properties of WRL-68
RT   cells in culture.";
RL   In Vitro Cell. Dev. Biol. Anim. 30:366-371(1994).
RX   PubMed=8389256; DOI=10.1093/carcin/14.5.987;
RA   Hsu I.C., Tokiwa T., Bennett W., Metcalf R.A., Welsh J.A., Sun T.,
RA   Harris C.C.;
RT   "p53 gene mutation and integrated hepatitis B viral DNA sequences in
RT   human liver cancer cell lines.";
RL   Carcinogenesis 14:987-992(1993).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).