ID   UF-1
AC   CVCL_0567
DR   MCCL; MCC:0000472
DR   cancercelllines; CVCL_0567
DR   Cosmic; 787485
DR   Cosmic; 975309
DR   Cosmic; 1281359
DR   Wikidata; Q54990130
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8781440;
RX   PubMed=11438209;
RX   PubMed=15234573;
CC   Population: Japanese.
CC   Characteristics: Resistant to all-trans retinoic acid (ATRA).
CC   Doubling time: 72 hours (PubMed=8781440); 96 hours (PubMed=15234573).
CC   Sequence variation: Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (PubMed=8781440).
CC   Sequence variation: Mutation; HGNC; HGNC:9864; RARA; Simple; p.Arg276Trp (c.826C>T); ClinVar=VCV000191350; Zygosity=Unspecified; Note=Equivalent to p.Arg611Trp in the PML-RARA fusion protein (PubMed=11438209).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   33Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 19
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RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=8781440; DOI=10.1182/blood.V88.5.1824.1824;
RA   Kizaki M., Matsushita H., Takayama N., Muto A., Ueno H., Awaya N.,
RA   Kawai Y., Asou H., Kamada N., Ikeda Y.;
RT   "Establishment and characterization of a novel acute promyelocytic
RT   leukemia cell line (UF-1) with retinoic acid-resistant features.";
RL   Blood 88:1824-1833(1996).
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RX   PubMed=11438209; DOI=10.1016/S0301-472X(01)00651-8;
RA   Takayama N., Kizaki M., Hida T., Kinjo K., Ikeda Y.;
RT   "Novel mutation in the PML/RARalpha chimeric gene exhibits
RT   dramatically decreased ligand-binding activity and confers acquired
RT   resistance to retinoic acid in acute promyelocytic leukemia.";
RL   Exp. Hematol. 29:864-872(2001).
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RX   PubMed=15234573; DOI=10.1016/j.leukres.2003.12.017;
RA   Sato A., Imaizumi M., Hoshi Y., Rikiishi T., Fujii K., Kizaki M.,
RA   Kagechika H., Kakizuka A., Hayashi Y., Iinuma K.;
RT   "Alteration in the cellular response to retinoic acid of a human acute
RT   promyelocytic leukemia cell line, UF-1, carrying a patient-derived
RT   mutant PML-RARalpha chimeric gene.";
RL   Leuk. Res. 28:959-967(2004).
//