ID   SK-MEL-28
AC   CVCL_0526
SY   SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36
DR   BTO; BTO:0002131
DR   CLO; CLO_0009043
DR   EFO; EFO_0003081
DR   MCCL; MCC:0000426
DR   CLDB; cl4321
DR   CLDB; cl4954
DR   AddexBio; C0020001/66
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; HTB-72
DR   BCRJ; 0289
DR   BioSample; SAMN03470899
DR   BioSample; SAMN03472092
DR   BioSample; SAMN03472754
DR   BioSample; SAMN10987689
DR   cancercelllines; CVCL_0526
DR   Cell_Model_Passport; SIDM00081
DR   CGH-DB; 9317-4
DR   ChEMBL-Cells; CHEMBL3308494
DR   ChEMBL-Targets; CHEMBL614919
DR   CLS; 300337
DR   Cosmic; 686472
DR   Cosmic; 686476
DR   Cosmic; 687442
DR   Cosmic; 706106
DR   Cosmic; 721824
DR   Cosmic; 851050
DR   Cosmic; 874384
DR   Cosmic; 874446
DR   Cosmic; 875887
DR   Cosmic; 886831
DR   Cosmic; 888846
DR   Cosmic; 897491
DR   Cosmic; 898252
DR   Cosmic; 905230
DR   Cosmic; 905954
DR   Cosmic; 928748
DR   Cosmic; 932712
DR   Cosmic; 933135
DR   Cosmic; 974072
DR   Cosmic; 974262
DR   Cosmic; 1006554
DR   Cosmic; 1007156
DR   Cosmic; 1022271
DR   Cosmic; 1045407
DR   Cosmic; 1047687
DR   Cosmic; 1054859
DR   Cosmic; 1067227
DR   Cosmic; 1092633
DR   Cosmic; 1102386
DR   Cosmic; 1109809
DR   Cosmic; 1132589
DR   Cosmic; 1155280
DR   Cosmic; 1155570
DR   Cosmic; 1175872
DR   Cosmic; 1183772
DR   Cosmic; 1187579
DR   Cosmic; 1221590
DR   Cosmic; 1238109
DR   Cosmic; 1295337
DR   Cosmic; 1303055
DR   Cosmic; 1305368
DR   Cosmic; 1312350
DR   Cosmic; 1425350
DR   Cosmic; 1458966
DR   Cosmic; 1459645
DR   Cosmic; 1477319
DR   Cosmic; 1477408
DR   Cosmic; 1507598
DR   Cosmic; 1598350
DR   Cosmic; 1665022
DR   Cosmic; 1669144
DR   Cosmic; 1995635
DR   Cosmic; 1998476
DR   Cosmic; 2159448
DR   Cosmic; 2479251
DR   Cosmic; 2560253
DR   Cosmic; 2651877
DR   Cosmic-CLP; 905954
DR   DepMap; ACH-000615
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   EGA; EGAS00001002554
DR   GDSC; 905954
DR   GEO; GSM2115
DR   GEO; GSM50205
DR   GEO; GSM50267
DR   GEO; GSM156050
DR   GEO; GSM171012
DR   GEO; GSM188226
DR   GEO; GSM188256
DR   GEO; GSM188315
DR   GEO; GSM206543
DR   GEO; GSM228378
DR   GEO; GSM274690
DR   GEO; GSM276739
DR   GEO; GSM743468
DR   GEO; GSM750825
DR   GEO; GSM784506
DR   GEO; GSM799357
DR   GEO; GSM799420
DR   GEO; GSM844690
DR   GEO; GSM847116
DR   GEO; GSM887584
DR   GEO; GSM888667
DR   GEO; GSM952581
DR   GEO; GSM1138790
DR   GEO; GSM1153427
DR   GEO; GSM1153428
DR   GEO; GSM1181282
DR   GEO; GSM1181283
DR   GEO; GSM1588919
DR   GEO; GSM1670439
DR   GEO; GSM1671969
DR   GEO; GSM1671970
DR   GEO; GSM1671974
DR   GEO; GSM1671983
DR   GEO; GSM1671986
DR   GEO; GSM1671991
DR   GEO; GSM1671996
DR   GEO; GSM1672002
DR   GEO; GSM1672006
DR   GEO; GSM1672032
DR   GEO; GSM1672043
DR   GEO; GSM1672047
DR   GEO; GSM1672049
DR   GEO; GSM1672050
DR   GEO; GSM1672054
DR   GEO; GSM1672056
DR   GEO; GSM1672060
DR   GEO; GSM1672061
DR   GEO; GSM2124651
DR   GEO; GSM3039512
DR   IARC_TP53; 26113
DR   ICLC; HTL99010
DR   LiGeA; CCLE_529
DR   LINCS_HMS; 51101
DR   LINCS_LDP; LCL-2092
DR   NCI-DTP; SK-MEL-28
DR   PharmacoDB; SKMEL28_1396_2019
DR   PRIDE; PXD005942
DR   PRIDE; PXD005946
DR   PRIDE; PXD007000
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0526
DR   PubChem_Cell_line; CVCL_0526
DR   RCB; RCB1930
DR   SKY/M-FISH/CGH; 2745
DR   TKG; TKG 0333
DR   Wikidata; Q54954013
RX   DOI=10.1007/978-1-4615-7228-2_39;
RX   Patent=US4591572;
RX   PubMed=313568;
RX   PubMed=327080;
RX   PubMed=978138;
RX   PubMed=1067619;
RX   PubMed=1716514;
RX   PubMed=2041050;
RX   PubMed=2068080;
RX   PubMed=2983346;
RX   PubMed=3335022;
RX   PubMed=3518877;
RX   PubMed=6197381;
RX   PubMed=6203018;
RX   PubMed=6349783;
RX   PubMed=6582512;
RX   PubMed=6864164;
RX   PubMed=6933476;
RX   PubMed=7017212;
RX   PubMed=7175440;
RX   PubMed=7718330;
RX   PubMed=7999427;
RX   PubMed=9354451;
RX   PubMed=9466661;
RX   PubMed=9598804;
RX   PubMed=10700174;
RX   PubMed=10766161;
RX   PubMed=11016658;
RX   PubMed=11121133;
RX   PubMed=12068308;
RX   PubMed=12479222;
RX   PubMed=14692828;
RX   PubMed=14871852;
RX   PubMed=15009714;
RX   PubMed=15299072;
RX   PubMed=15467732;
RX   PubMed=15748285;
RX   PubMed=17088437;
RX   PubMed=17260012;
RX   PubMed=17308088;
RX   PubMed=17363583;
RX   PubMed=17516929;
RX   PubMed=18277095;
RX   PubMed=18790768;
RX   PubMed=19147755;
RX   PubMed=19372543;
RX   PubMed=19799798;
RX   PubMed=20041153;
RX   PubMed=20164919;
RX   PubMed=20406486;
RX   PubMed=21424129;
RX   PubMed=21725359;
RX   PubMed=22068913;
RX   PubMed=22347499;
RX   PubMed=22384151;
RX   PubMed=22460905;
RX   PubMed=22628656;
RX   PubMed=23285177;
RX   PubMed=23856246;
RX   PubMed=23933261;
RX   PubMed=24279929;
RX   PubMed=24576830;
RX   PubMed=24670534;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25950383;
RX   PubMed=25960936;
RX   PubMed=26405815;
RX   PubMed=26589293;
RX   PubMed=26673621;
RX   PubMed=27087056;
RX   PubMed=27377824;
RX   PubMed=27397505;
RX   PubMed=27807467;
RX   PubMed=28196595;
RX   PubMed=29492214;
RX   PubMed=30674989;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=35839778;
WW   https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
WW   https://strap.nci.nih.gov/celline_detail.php?sample_id=47
WW   https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-melanoma-cell-line-sk-mel-28
WW   https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: NCI-60 cancer cell line panel.
CC   From: Memorial Sloan Kettering Cancer Center; New York; USA.
CC   Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-524.
CC   Population: Caucasian.
CC   Characteristics: Lightly pigmented.
CC   Doubling time: 27 hours (PubMed=7718330); 72 hours (PubMed=12479222); 26.9 hours (PubMed=20406486); 35.1 hours (NCI-DTP=SK-MEL-28).
CC   HLA typing: A*11:01:01; B*40:01; C*03:04:01; DPB1*03:01:01; DQB1*03:02; DRB1*04:04 (PubMed=15748285).
CC   HLA typing: A*11:01,11:01; B*40:01,40:01; C*03:03,03:03; DQA1*03:02,03:02; DQB1*03:02,03:02; DRB1*04:04,04:04 (PubMed=25960936).
CC   HLA typing: A*11:01,11:01; B*40:01,40:01; C*03:04,03:04; DQA1*03:02,05:02; DQB1*03:02,03:02 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (PubMed=12068308; PubMed=15467732; PubMed=17088437; PubMed=17260012; PubMed=17363583; PubMed=19799798; PubMed=24576830; PubMed=26405815; PubMed=29492214; Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 1773; CDK4; Simple; p.Arg24Cys (c.70C>T); ClinVar=VCV000016928; Zygosity=Heterozygous (PubMed=9598804; Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Pro753Ser (c.2257C>T); ClinVar=VCV000376081; Zygosity=Homozygous (PubMed=17088437; Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Thr167Ala (c.499A>G); ClinVar=VCV001686107; Zygosity=Homozygous (PubMed=10766161; PubMed=17260012; PubMed=17363583; Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.-57A>C (c.161A>C) (A161C); ClinVar=VCV000242210; Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Leu145Arg (c.434T>G); ClinVar=VCV001027110; Zygosity=Homozygous (PubMed=17088437; PubMed=17260012; PubMed=18277095; Cosmic-CLP; DepMap).
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Exosome proteome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Fluorescence phenotype profiling.
CC   Omics: lncRNA expression profiling.
CC   Omics: Metabolome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=1.75%; Native American=0.56%; East Asian, North=3%; East Asian, South=1.38%; South Asian=8.29%; European, North=20.11%; European, South=64.91% (PubMed=30894373).
CC   Discontinued: RCB; RCB1930; true.
CC   Discontinued: TKG; TKG 0333; true.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Melanocyte of skin; CL=CL_1000458.
ST   Source(s): AddexBio; ATCC; CLS; Cosmic-CLP; PubMed=19372543; PubMed=25877200; PubMed=27087056; RCB
ST   Amelogenin: X,Y
ST   CSF1PO: 10 (PubMed=19372543; PubMed=25877200)
ST   CSF1PO: 10,12 (AddexBio; ATCC; CLS; Cosmic-CLP; PubMed=27087056; RCB)
ST   D13S317: 11,12
ST   D16S539: 9,12
ST   D18S51: 12,16
ST   D19S433: 14
ST   D21S11: 28,29
ST   D2S1338: 18
ST   D3S1358: 16,18
ST   D5S818: 11,13 (AddexBio; ATCC; Cosmic-CLP; PubMed=27087056; RCB)
ST   D5S818: 13 (CLS; PubMed=19372543; PubMed=25877200)
ST   D7S820: 9.3,10 (AddexBio; ATCC)
ST   D7S820: 10 (CLS; Cosmic-CLP; PubMed=19372543; PubMed=25877200; PubMed=27087056; RCB)
ST   D8S1179: 13
ST   FGA: 19
ST   Penta D: 9,10
ST   Penta E: 8,12
ST   TH01: 7
ST   TPOX: 8,12 (AddexBio; ATCC; CLS; Cosmic-CLP; PubMed=27087056; RCB)
ST   TPOX: 12 (PubMed=19372543; PubMed=25877200)
ST   vWA: 16,19 (AddexBio; ATCC; CLS; Cosmic-CLP; PubMed=25877200; PubMed=27087056; RCB)
ST   vWA: 19 (PubMed=19372543)
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 47
//
RX   DOI=10.1007/978-1-4615-7228-2_39;
RA   Houghton A.N., Oettgen H.F., Old L.J.;
RT   "Malignant melanoma. Current status of the search for melanoma-specific
RT   antigens.";
RL   (In) Immunodermatology. Comprehensive Immunology, Vol 7; Safai B., Good R.A. (eds.); pp.557-576; Springer; Boston (1981).
//
RX   Patent=US4591572;
RA   Mattes M.J., Thomson T.M., Old L.J., Lloyd K.O.;
RT   "Pigmentation associated, differentiation antigen of human melanoma
RT   and autologous antibody.";
RL   Patent number US4591572, 27-May-1986.
//
RX   PubMed=313568; DOI=10.1073/pnas.76.6.2898;
RA   Carey T.E., Lloyd K.O., Takahashi T., Travassos L.R., Old L.J.;
RT   "AU cell-surface antigen of human malignant melanoma: solubilization
RT   and partial characterization.";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:2898-2902(1979).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh J., Fogh J.M., Orfeo T.;
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=978138; DOI=10.1084/jem.144.4.873;
RA   Shiku H., Takahashi T., Oettgen H.F., Old L.J.;
RT   "Cell surface antigens of human malignant melanoma. II. Serological
RT   typing with immune adherence assays and definition of two new surface
RT   antigens.";
RL   J. Exp. Med. 144:873-881(1976).
//
RX   PubMed=1067619; DOI=10.1073/pnas.73.9.3278;
RA   Carey T.E., Takahashi T., Resnick-Silverman L.A., Oettgen H.F.,
RA   Old L.J.;
RT   "Cell surface antigens of human malignant melanoma: mixed
RT   hemadsorption assays for humoral immunity to cultured autologous
RT   melanoma cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 73:3278-3282(1976).
//
RX   PubMed=1716514;
RA   Albino A.P., Davis B.M., Nanus D.M.;
RT   "Induction of growth factor RNA expression in human malignant
RT   melanoma: markers of transformation.";
RL   Cancer Res. 51:4815-4820(1991).
//
RX   PubMed=2041050; DOI=10.1093/jnci/83.11.757;
RA   Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K.D.,
RA   Vistica D.T., Hose C.D., Langley J., Cronise P., Vaigro-Wolff A.,
RA   Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.;
RT   "Feasibility of a high-flux anticancer drug screen using a diverse
RT   panel of cultured human tumor cell lines.";
RL   J. Natl. Cancer Inst. 83:757-766(1991).
//
RX   PubMed=2068080; DOI=10.1073/pnas.88.14.6028;
RA   Cornil I., Theodorescu D., Man S., Herlyn M., Jambrosic J.A.,
RA   Kerbel R.S.;
RT   "Fibroblast cell interactions with human melanoma cells affect tumor
RT   cell growth as a function of tumor progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:6028-6032(1991).
//
RX   PubMed=2983346; DOI=10.1073/pnas.82.5.1470;
RA   Dracopoli N.C., Houghton A.N., Old L.J.;
RT   "Loss of polymorphic restriction fragments in malignant melanoma:
RT   implications for tumor heterogeneity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:1470-1474(1985).
//
RX   PubMed=3335022;
RA   Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J.,
RA   Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.;
RT   "Feasibility of drug screening with panels of human tumor cell lines
RT   using a microculture tetrazolium assay.";
RL   Cancer Res. 48:589-601(1988).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=6197381; DOI=10.1002/ijc.2910320610;
RA   Mattes M.J., Thomson T.M., Old L.J., Lloyd K.O.;
RT   "A pigmentation-associated, differentiation antigen of human melanoma
RT   defined by a precipitating antibody in human serum.";
RL   Int. J. Cancer 32:717-721(1983).
//
RX   PubMed=6203018; DOI=10.1111/j.1348-0421.1984.tb00673.x;
RA   Maezawa N., Yano A.;
RT   "Two distinct cytotoxic T lymphocyte subpopulations in patients with
RT   Vogt-Koyanagi-Harada disease that recognize human melanoma cells.";
RL   Microbiol. Immunol. 28:219-231(1984).
//
RX   PubMed=6349783; DOI=10.1002/1097-0142(19830915)52:6<949::AID-CNCR2820520602>3.0.CO;2-2;
RA   Dantas M.E., Brown J.P., Thomas M.R., Robinson W.A., Glode L.M.;
RT   "Detection of melanoma cells in bone marrow using monoclonal
RT   antibodies. A comparison of fluorescence activated cell sorting (FACS)
RT   and conventional immunofluorescence (IF).";
RL   Cancer 52:949-953(1983).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568;
RA   Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.;
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=6864164; DOI=10.1084/jem.158.1.53;
RA   Houghton A.N., Brooks H., Cote R.J., Taormina M.C., Oettgen H.F.,
RA   Old L.J.;
RT   "Detection of cell surface and intracellular antigens by human
RT   monoclonal antibodies. Hybrid cell lines derived from lymphocytes of
RT   patients with malignant melanoma.";
RL   J. Exp. Med. 158:53-65(1983).
//
RX   PubMed=6933476; DOI=10.1073/pnas.77.7.4260;
RA   Houghton A.N., Taormina M.C., Ikeda H., Watanabe T., Oettgen H.F.,
RA   Old L.J.;
RT   "Serological survey of normal humans for natural antibody to cell
RT   surface antigens of melanoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:4260-4264(1980).
//
RX   PubMed=7017212; DOI=10.1093/jnci/66.6.1003;
RA   Pollack M.S., Heagney S.D., Livingston P.O., Fogh J.;
RT   "HLA-A, B, C and DR alloantigen expression on forty-six cultured human
RT   tumor cell lines.";
RL   J. Natl. Cancer Inst. 66:1003-1012(1981).
//
RX   PubMed=7175440; DOI=10.1084/jem.156.6.1755;
RA   Houghton A.N., Eisinger M., Albino A.P., Cairncross J.G., Old L.J.;
RT   "Surface antigens of melanocytes and melanomas. Markers of melanocyte
RT   differentiation and melanoma subsets.";
RL   J. Exp. Med. 156:1755-1766(1982).
//
RX   PubMed=7718330; DOI=10.1016/0959-8049(94)00472-H;
RA   Baguley B.C., Marshall E.S., Whittaker J.R., Dotchin M.C., Nixon J.,
RA   McCrystal M.R., Finlay G.J., Matthews J.H.L., Holdaway K.M.,
RA   van Zijl P.;
RT   "Resistance mechanisms determining the in vitro sensitivity to
RT   paclitaxel of tumour cells cultured from patients with ovarian
RT   cancer.";
RL   Eur. J. Cancer 31:230-237(1995).
//
RX   PubMed=7999427; DOI=10.1016/0959-8049(94)90188-0;
RA   Marshall E.S., Matthews J.H.L., Shaw J.H.F., Nixon J., Tumewu P.,
RA   Finlay G.J., Holdaway K.M., Baguley B.C.;
RT   "Radiosensitivity of new and established human melanoma cell lines:
RT   comparison of [3H]thymidine incorporation and soft agar clonogenic
RT   assays.";
RL   Eur. J. Cancer 30:1370-1376(1994).
//
RX   PubMed=9354451;
RA   Castellano M., Pollock P.M., Walters M.K., Sparrow L.E., Down L.M.,
RA   Gabrielli B.G., Parsons P.G., Hayward N.K.;
RT   "CDKN2A/p16 is inactivated in most melanoma cell lines.";
RL   Cancer Res. 57:4868-4875(1997).
//
RX   PubMed=9466661; DOI=10.1002/(SICI)1097-0215(19980209)75:4<590::AID-IJC16>3.0.CO;2-D;
RA   White C.A., Thomson S.A., Cooper L., van Endert P.M., Tampe R.,
RA   Coupar B., Qiu L., Parsons P.G., Moss D.J., Khanna R.;
RT   "Constitutive transduction of peptide transporter and HLA genes
RT   restores antigen processing function and cytotoxic T cell-mediated
RT   immune recognition of human melanoma cells.";
RL   Int. J. Cancer 75:590-595(1998).
//
RX   PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N;
RA   Walker G.J., Flores J.F., Glendening J.M., Lin A.H.-T., Markl I.D.C.,
RA   Fountain J.W.;
RT   "Virtually 100% of melanoma cell lines harbor alterations at the DNA
RT   level within CDKN2A, CDKN2B, or one of their downstream targets.";
RL   Genes Chromosomes Cancer 22:157-163(1998).
//
RX   PubMed=10700174; DOI=10.1038/73432;
RA   Ross D.T., Scherf U., Eisen M.B., Perou C.M., Rees C., Spellman P.T.,
RA   Iyer V.R., Jeffrey S.S., van de Rijn M., Waltham M.C., Pergamenschikov A.,
RA   Lee J.C.F., Lashkari D., Shalon D., Myers T.G., Weinstein J.N.,
RA   Botstein D., Brown P.O.;
RT   "Systematic variation in gene expression patterns in human cancer cell
RT   lines.";
RL   Nat. Genet. 24:227-235(2000).
//
RX   PubMed=10766161;
RA   Tsao H., Zhang X., Fowlkes K., Haluska F.G.;
RT   "Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous
RT   melanoma cell lines.";
RL   Cancer Res. 60:1800-1804(2000).
//
RX   PubMed=11016658;
RA   Girnita L., Girnita A., Brodin B., Xie Y.-T., Nilsson G., Dricu A.,
RA   Lundeberg J., Wejde J., Bartolazzi A., Wiman K.G., Larsson O.;
RT   "Increased expression of insulin-like growth factor I receptor in
RT   malignant cells expressing aberrant p53: functional impact.";
RL   Cancer Res. 60:5278-5283(2000).
//
RX   PubMed=11121133; DOI=10.1046/j.1523-1747.2000.00199.x;
RA   Lacal P.M., Failla C.M., Pagani E., Odorisio T., Schietroma C.,
RA   Falcinelli S., Zambruno G., D'Atri S.;
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RT   mechanisms of intrinsic and adaptive resistance to BRAF inhibition in
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