Cellosaurus cell line NRK-52E (CVCL

Cellosaurus NRK-52E (CVCL_0468)

[Text version]

Cell line name

NRK-52E

Synonyms

NRK 52E; NRK52E; NRK clone 52E; Normal Rat Kidney-52E; NRK-E52

Accession

CVCL_0468

Resource Identification Initiative

To cite this cell line use: NRK-52E (RRID:CVCL_0468)

Comments

Doubling time: ~45 hours (DSMZ=ACC-199).
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Species of origin

Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Osborne-Mendel; RS=RS:0000629.

Hierarchy

Parent: CVCL_3758 (NRK)
Children:

CVCL_E1AA (Ubigene NRK-52E Slc39a7 KO)

Category

Spontaneously immortalized cell line

Web pages

https://www.atcc.org/en/support/technical-support/faqs/lifespan-of-the-cell-line-nrk-52e-atcc-crl-1571

Publications

PubMed=304450; DOI=10.1002/jcp.1040940311
De Larco J.E., Todaro G.J.
Epithelioid and fibroblastic rat kidney cell clones: epidermal growth factor (EGF) receptors and the effect of mouse sarcoma virus transformation.
J. Cell. Physiol. 94:335-342(1978)

PubMed=7732277; DOI=10.1177/019262339402200604
Davis M.A., Smith M.W., Chang S.H., Trump B.F.
Characterization of a renal epithelial cell model of apoptosis using okadaic acid and the NRK-52E cell line.
Toxicol. Pathol. 22:595-605(1994)

PubMed=29460274; DOI=10.1002/bit.26574
Yeste J., Martinez-Gimeno L., Illa X., Laborda P., Guimera A., Sanchez-Marin J.P., Villa R., Gimenez I.
A perfusion chamber for monitoring transepithelial NaCl transport in an in vitro model of the renal tubule.
Biotechnol. Bioeng. 115:1604-1613(2018)

PubMed=33122286; DOI=10.1681/ASN.2020010009; PMCID=PMC7894662
Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.
Transcriptomes of major proximal tubule cell culture models.
J. Am. Soc. Nephrol. 32:86-97(2021)

Cross-references

Cell line collections (Providers)

ATCC; CRL-1571
BCRC; 60086
CLS; 305196
DSMZ; ACC-199
ECACC; 87012902
JCRB; IFO50480

Cell line databases/resources