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Cellosaurus NKL (CVCL_0466)

[Text version]
Cell line name NKL
Accession CVCL_0466
Resource Identification Initiative To cite this cell line use: NKL (RRID:CVCL_0466)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: IL2 dependent.
Doubling time: 24-48 hours (PubMed=8599969).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Natural killer cell; CL=CL_0000623.
Disease Natural killer cell lymphoblastic leukemia/lymphoma (NCIt: C82217)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=8599969
Robertson M.J., Cochran K.J., Cameron C., Le J.-M., Tantravahi R., Ritz J.
Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia.
Exp. Hematol. 24:406-415(1996)

PubMed=10803505; DOI=10.1038/sj.leu.2401778
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of natural killer cell leukemia-lymphoma.
Leukemia 14:777-782(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=30054012; DOI=10.1016/j.molimm.2018.07.015
Gunesch J.T., Angelo L.S., Mahapatra S., Deering R.P., Kowalko J.E., Sleiman P., Tobias J.W., Monaco-Shawver L., Orange J.S., Mace E.M.
Genome-wide analyses and functional profiling of human NK cell lines.
Mol. Immunol. 115:64-75(2019)

Cross-references
Cell line databases/resources MCCL; MCC:0000364
cancercelllines; CVCL_0466
Cell_Model_Passport; SIDM01880
DepMap; ACH-001143
Lonza; 145
Encyclopedic resources Wikidata; Q54930680
Polymorphism and mutation databases Cosmic; 1534875
Cosmic; 2025324
Cosmic; 2785207
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number15