ID   MCF-7/2a
AC   CVCL_0412
SY   MCF-7/2A; MCF7/2a; MCF-7 clone 2A
DR   BTO; BTO:0002270
DR   MCCL; MCC:0000308
DR   cancercelllines; CVCL_0412
DR   Wikidata; Q54904345
RX   PubMed=10766749;
RX   PubMed=15531579;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:29063; L-mimosine.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Caution: There is confusion in the literature between estrogen-independent MCF-7:2A (Cellosaurus=CVCL_4Y53), L-mimosine-resistant MCF-7/2a (Cellosaurus=CVCL_0412) and EREwtcluc transfected MCF-7-2a (Cellosaurus=CVCL_4Y54).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 22
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RX   PubMed=10766749; DOI=10.1074/jbc.M001610200;
RA   Oppenheim E.W., Nasrallah I.M., Mastri M.G., Stover P.J.;
RT   "Mimosine is a cell-specific antagonist of folate metabolism.";
RL   J. Biol. Chem. 275:19268-19274(2000).
//
RX   PubMed=15531579; DOI=10.1074/jbc.M410467200;
RA   Perry C., Sastry R., Nasrallah I.M., Stover P.J.;
RT   "Mimosine attenuates serine hydroxymethyltransferase transcription by
RT   chelating zinc. Implications for inhibition of DNA replication.";
RL   J. Biol. Chem. 280:396-400(2005).
//