ID   LAD 2
AC   CVCL_0387
SY   LAD2; LAD-2; Laboratory of Allergic Diseases 2
DR   BTO; BTO:0004139
DR   MCCL; MCC:0000282
DR   ChEMBL-Cells; CHEMBL4483145
DR   ChEMBL-Targets; CHEMBL4483253
DR   PubChem_Cell_line; CVCL_0387
DR   Wikidata; Q54901897
RX   DOI=10.1016/j.jaci.2013.12.226;
RX   DOI=10.1016/j.jaci.2018.12.550;
RX   PubMed=12801524;
RX   PubMed=25149487;
RX   PubMed=25195635;
RX   PubMed=31698677;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=LAD2
CC   Characteristics: KITLG dependent.
CC   Doubling time: ~14 days (DOI=10.1016/j.jaci.2018.12.550).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: Mast cell; CL=CL_0000097.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5220 ! LAD 1
SX   Male
AG   44Y
CA   Factor-dependent cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 16
//
RX   DOI=10.1016/j.jaci.2013.12.226;
RA   Kirshenbaum A.S., Petrik A., Walsh R., Vepa S., Metcalfe D.D.;
RT   "Worldwide impact Of LAD2 mast cell line on mast cell biology
RT   research.";
RL   J. Allergy Clin. Immunol. 133 Suppl. 1:AB57-AB57(2014).
//
RX   DOI=10.1016/j.jaci.2018.12.550;
RA   Kirshenbaum A.S., Yin Y., Sundstrom J.B., Bandara G., Metcalfe D.D.;
RT   "Characterization and comparison of human LAD1 mast cells with human
RT   LAD2 mast cells.";
RL   J. Allergy Clin. Immunol. 143 Suppl. 1:AB180-AB180(2019).
//
RX   PubMed=12801524; DOI=10.1016/S0145-2126(02)00343-0;
RA   Kirshenbaum A.S., Akin C., Wu Y.-L., Rottem M., Goff J.P., Beaven M.A.,
RA   Rao V.K., Metcalfe D.D.;
RT   "Characterization of novel stem cell factor responsive human mast cell
RT   lines LAD 1 and 2 established from a patient with mast cell
RT   sarcoma/leukemia; activation following aggregation of FcepsilonRI or
RT   FcgammaRI.";
RL   Leuk. Res. 27:677-682(2003).
//
RX   PubMed=25149487; DOI=10.1007/978-1-4939-1173-8_8;
RA   Passante E.;
RT   "Mast cell and basophil cell lines: a compendium.";
RL   Methods Mol. Biol. 1192:101-113(2014).
//
RX   PubMed=25195635; DOI=10.1159/000365729; PMCID=PMC4201868;
RA   Kirshenbaum A.S., Petrik A., Walsh R., Kirby T.L., Vepa S., Wangsa D.,
RA   Ried T., Metcalfe D.D.;
RT   "A ten-year retrospective analysis of the distribution, use and
RT   phenotypic characteristics of the LAD2 human mast cell line.";
RL   Int. Arch. Allergy Immunol. 164:265-270(2014).
//
RX   PubMed=31698677; DOI=10.3390/ijms20225520; PMCID=PMC6888318;
RA   Kirshenbaum A.S., Yin Y.-Z., Sundstrom J.B., Bandara G., Metcalfe D.D.;
RT   "Description and characterization of a novel human mast cell line for
RT   scientific study.";
RL   Int. J. Mol. Sci. 20:5520.1-5520.9(2019).
//