ID   L6
AC   CVCL_0385
SY   L-6; L-6 myoblast
DR   BTO; BTO:0002809
DR   CLO; CLO_0007203
DR   EFO; EFO_0022767
DR   MCCL; MCC:0000280
DR   CLDB; cl3142
DR   CLDB; cl5220
DR   ATCC; CRL-1458
DR   BCRJ; 0141
DR   CCRID; 1101RAT-PUMC000192
DR   CCRID; 3101RATGNR4
DR   ChEMBL-Cells; CHEMBL3308469
DR   ChEMBL-Targets; CHEMBL614793
DR   IZSLER; BS CL 134
DR   JCRB; IFO50364
DR   JCRB; JCRB9081
DR   KCLB; 21458
DR   Kerafast; ESK201-FP
DR   Lonza; 927
DR   PRIDE; PXD002557
DR   PubChem_Cell_line; CVCL_0385
DR   Wikidata; Q54901051
RX   PubMed=1311324;
RX   PubMed=5245982;
RX   PubMed=5481965;
RX   PubMed=7297605;
RX   PubMed=10484371;
RX   PubMed=33117511;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/l/cell-lines-detail-130.html
CC   Transformant: ChEBI; CHEBI:34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
CC   Anecdotal: Called L6 by David Yaffe because he and Sara Neuman established the cell line during the Six-Day war in 1967 (PubMed=33117511).
CC   Derived from site: In situ; Skeletal muscle; UBERON=UBERON_0001134.
CC   Cell type: Myoblast; CL=CL_0000056.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Male
AG   1D
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 28
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RX   PubMed=1311324; DOI=10.1016/S0021-9258(18)42923-7;
RA   Mitsumoto Y., Klip A.;
RT   "Development regulation of the subcellular distribution and
RT   glycosylation of GLUT1 and GLUT4 glucose transporters during
RT   myogenesis of L6 muscle cells.";
RL   J. Biol. Chem. 267:4957-4962(1992).
//
RX   PubMed=5245982; DOI=10.1073/pnas.61.2.477; PMCID=PMC225183;
RA   Yaffe D.;
RT   "Retention of differentiation potentialities during prolonged
RT   cultivation of myogenic cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 61:477-483(1968).
//
RX   PubMed=5481965; DOI=10.1016/S0012-1606(70)80004-5;
RA   Richler C., Yaffe D.;
RT   "The in vitro cultivation and differentiation capacities of myogenic
RT   cell lines.";
RL   Dev. Biol. 23:1-22(1970).
//
RX   PubMed=7297605; DOI=10.1016/0014-4827(81)90032-X;
RA   Parfett C.L.J., Jamieson J.C., Wright J.A.;
RT   "A correlation between loss of fusion potential and defective
RT   formation of mannose-linked lipid intermediates in independent
RT   concanavalin A-resistant myoblast cell lines.";
RL   Exp. Cell Res. 136:1-14(1981).
//
RX   PubMed=10484371; DOI=10.1152/ajpendo.1999.277.3.E572;
RA   Ueyama A., Yaworsky K.L., Wang Q.-H., Ebina Y., Klip A.;
RT   "GLUT-4myc ectopic expression in L6 myoblasts generates a
RT   GLUT-4-specific pool conferring insulin sensitivity.";
RL   Am. J. Physiol. 277:E572-E578(1999).
//
RX   PubMed=33117511; DOI=10.4081/ejtm.2020.9306; PMCID=PMC7582454;
RA   Yablonka-Reuveni Z., Stockdale F.E., Nudel U., Israeli D., Blau H.M.,
RA   Shainberg A., Neuman S., Kessler-Icekson G., Krull E.M., Paterson B.,
RA   Fuchs O.S., Greenberg D., Sarig R., Halevy O., Ozawa E.,
RA   Katcoff D.J.;
RT   "Farewell to professor David Yaffe -- a pillar of the myogenesis
RT   field.";
RL   Eur. J. Transl. Myol. 30:9306.1-9306.16(2020).
//