ID   KB
AC   CVCL_0372
SY   KB (HeLa derivative); HeLa-KB; Strain KB
DR   BTO; BTO:0000665
DR   CLO; CLO_0007074
DR   MCCL; MCC:0000267
DR   CLDB; cl3001
DR   CLDB; cl3002
DR   CLDB; cl3003
DR   CLDB; cl3004
DR   CLDB; cl3005
DR   CLDB; cl3006
DR   ATCC; CCL-17
DR   BCRC; 60017
DR   BCRJ; 0128
DR   BioSample; SAMN03151730
DR   CCLV; CCLV-RIE 0016
DR   CCRID; 1101HUM-PUMC000163
DR   ChEMBL-Cells; CHEMBL3307959
DR   ChEMBL-Targets; CHEMBL398
DR   CLS; 300446
DR   Cosmic; 753567
DR   Cosmic; 1042301
DR   Cosmic; 1339927
DR   Cosmic; 1969496
DR   Cosmic; 2301581
DR   Cosmic; 2546843
DR   DSMZ; ACC-136
DR   DSMZCellDive; ACC-136
DR   ECACC; 86103004
DR   ECACC; 94050408
DR   GEO; GSM1374595
DR   GEO; GSM1374596
DR   ICLC; HTL96014
DR   IZSLER; BS TCL 34
DR   JCRB; JCRB9027
DR   KCB; KCB 94020YJ
DR   KCLB; 10017
DR   MeSH; D007624
DR   NCBI_Iran; C152
DR   PubChem_Cell_line; CVCL_0372
DR   RCB; RCB1888
DR   TKG; TKG 0401
DR   TOKU-E; 2094
DR   Wikidata; Q28334825
RX   CelloPub=CLPUB00484;
RX   DOI=10.1007/978-1-4757-1647-4_13;
RX   DOI=10.1007/BF02618370;
RX   PubMed=656543;
RX   PubMed=1246601;
RX   PubMed=4203458;
RX   PubMed=4864103;
RX   PubMed=5641128;
RX   PubMed=5668122;
RX   PubMed=6988327;
RX   PubMed=8397027;
RX   PubMed=11416159;
RX   PubMed=11668190;
RX   PubMed=13254761;
RX   PubMed=13322936;
RX   PubMed=13431913;
RX   PubMed=14185313;
RX   PubMed=17254797;
RX   PubMed=17325662;
RX   PubMed=20143388;
RX   PubMed=23925245;
RX   PubMed=28455420;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/k/cell-lines-detail-494.html
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=1246601; PubMed=20143388). Originally thought to originate from an epidermal carcinoma of the mouth.
CC   Part of: KuDOS 95 cell line panel.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00010.
CC   Population: African American.
CC   Doubling time: ~30 hours (DSMZ=ACC-136).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Genome sequenced (low read coverage).
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Discontinued: BCRC; 60017; true.
CC   Discontinued: DSMZ; ACC-136; true.
CC   Discontinued: ECACC; 86103004; probable.
CC   Discontinued: ICLC; HTL96014; true.
CC   Discontinued: RCB; RCB1888; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): ATCC; CCRID; CLS; DSMZ; JCRB; KCLB; PubMed=11416159; PubMed=17254797; TKG
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 12,13.3 (ATCC; CLS; DSMZ; JCRB; KCLB; TKG)
ST   D13S317: 12,14 (CCRID; PubMed=17254797)
ST   D16S539: 9,10
ST   D18S51: 16
ST   D19S433: 13,14
ST   D21S11: 27,28
ST   D2S1338: 17
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 12,13
ST   FGA: 21
ST   Penta D: 8,15
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 38
//
RX   CelloPub=CLPUB00484;
RA   Xu Z.-H., Sun W.-W., Hang J.-B., Gao B.-L., Hu J.-A.;
RT   "RNA-seq identified a novel functional MET fusion in head and neck
RT   cancer 5-8F cell line.";
RL   Int. J. Clin. Exp. Pathol. 9:8308-8317(2016).
//
RX   DOI=10.1007/978-1-4757-1647-4_13;
RA   Biedler J.L.;
RT   "Chromosome abnormalities in human tumor cells in culture.";
RL   (In) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York (1975).
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   PubMed=656543; DOI=10.1016/S0006-3495(78)85487-3;
RA   Ehmann U.K., Cook K.H., Friedberg E.C.;
RT   "The kinetics of thymine dimer excision in ultraviolet-irradiated
RT   human cells.";
RL   Biophys. J. 22:249-264(1978).
//
RX   PubMed=1246601; DOI=10.1126/science.1246601;
RA   Nelson-Rees W.A., Flandermeyer R.R.;
RT   "HeLa cultures defined.";
RL   Science 191:96-98(1976).
//
RX   PubMed=4203458;
RA   Petricciani J.C., Wallace R.E., McCoy D.W.;
RT   "A comparison of three in vivo assays for cell tumorigenicity.";
RL   Cancer Res. 34:105-108(1974).
//
RX   PubMed=4864103;
RA   Gartler S.M.;
RT   "Genetic markers as tracers in cell culture.";
RL   Natl. Cancer Inst. Monogr. 26:167-195(1967).
//
RX   PubMed=5641128; DOI=10.1038/217750a0;
RA   Gartler S.M.;
RT   "Apparent Hela cell contamination of human heteroploid cell lines.";
RL   Nature 217:750-751(1968).
//
RX   PubMed=5668122; DOI=10.3181/00379727-128-33119;
RA   Peterson W.D. Jr., Stulberg C.S., Swanborg N.K., Robinson A.R.;
RT   "Glucose-6-phosphate dehydrogenase isoenzymes in human cell cultures
RT   determined by sucrose-agar gel and cellulose acetate zymograms.";
RL   Proc. Soc. Exp. Biol. Med. 128:772-776(1968).
//
RX   PubMed=6988327; DOI=10.1007/BF02831503;
RA   O'Brien S.J., Shannon J.E., Gail M.H.;
RT   "A molecular approach to the identification and individualization of
RT   human and animal cells in culture: isozyme and allozyme genetic
RT   signatures.";
RL   In Vitro 16:119-135(1980).
//
RX   PubMed=8397027;
RA   Ogura H., Yoshinouchi M., Kudo T., Imura M., Fujiwara T., Yabe Y.;
RT   "Human papillomavirus type 18 DNA in so-called HEP-2, KB and FL
RT   cells -- further evidence that these cells are HeLa cell derivatives.";
RL   Cell. Mol. Biol. 39:463-467(1993).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=11668190; DOI=10.1177/002215540104901105;
RA   Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.;
RT   "Immunocytochemical analysis of cell lines derived from solid
RT   tumors.";
RL   J. Histochem. Cytochem. 49:1369-1378(2001).
//
RX   PubMed=13254761; DOI=10.3181/00379727-89-21811;
RA   Eagle H.;
RT   "Propagation in a fluid medium of a human epidermoid carcinoma, strain
RT   KB.";
RL   Proc. Soc. Exp. Biol. Med. 89:362-364(1955).
//
RX   PubMed=13322936; DOI=10.3181/00379727-91-22263;
RA   Eagle H., Habel K., Rowe W.P., Huebner R.J.;
RT   "Viral susceptibility of a human carcinoma cell (strain KB).";
RL   Proc. Soc. Exp. Biol. Med. 91:361-364(1956).
//
RX   PubMed=13431913; DOI=10.3181/00379727-94-23044;
RA   Foley G.E., Handler A.H.;
RT   "Differentiation of normal and neoplastic cells maintained in tissue
RT   culture by implantation into normal hamsters.";
RL   Proc. Soc. Exp. Biol. Med. 94:661-664(1957).
//
RX   PubMed=14185313; DOI=10.1126/science.146.3641.241;
RG   Cell Culture Collection Committee;
RT   "Animal cell strains. The Cell Culture Collection Committee has
RT   assembled and certified 23 strains of animal cells.";
RL   Science 146:241-243(1964).
//
RX   PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001;
RA   Azari S., Ahmadi N., Tehrani M.J., Shokri F.;
RT   "Profiling and authentication of human cell lines using short tandem
RT   repeat (STR) loci: report from the National Cell Bank of Iran.";
RL   Biologicals 35:195-202(2007).
//
RX   PubMed=17325662; DOI=10.1038/sj.onc.1210330;
RA   Nakaya K., Yamagata H.D., Arita N., Nakashiro K.-i., Nose M., Miki T.,
RA   Hamakawa H.;
RT   "Identification of homozygous deletions of tumor suppressor gene FAT
RT   in oral cancer using CGH-array.";
RL   Oncogene 26:5300-5308(2007).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=23925245; DOI=10.1038/nature12064;
RA   Adey A., Burton J.N., Kitzman J.O., Hiatt J.B., Lewis A.P.,
RA   Martin B.K., Qiu R.-L., Lee C., Shendure J.;
RT   "The haplotype-resolved genome and epigenome of the aneuploid HeLa
RT   cancer cell line.";
RL   Nature 500:207-211(2013).
//
RX   PubMed=28455420; DOI=10.1158/0008-5472.CAN-16-2258;
RA   Vaughan L., Glanzel W., Korch C.T., Capes-Davis A.;
RT   "Widespread use of misidentified cell line KB (HeLa): incorrect
RT   attribution and its impact revealed through mining the scientific
RT   literature.";
RL   Cancer Res. 77:2784-2788(2017).
//