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Cellosaurus K562YO (CVCL_0369)

[Text version]
Cell line name K562YO
Accession CVCL_0369
Resource Identification Initiative To cite this cell line use: K562YO (RRID:CVCL_0369)
Comments Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=7506674
Ogawa K., Tashima M., Toi T., Sawai H., Sawada H., Fujita J., Maruyama Y., Okuma M.
Inhibition of erythroid differentiation by stem cell factor in K562 cells expressing the c-kit gene.
Exp. Hematol. 22:45-51(1994)

PubMed=7534132; DOI=10.1182/blood.V85.6.1496.bloodjournal8561496
Ogawa K., Takeda Y., Tashima M., Sawai H., Toi T., Okazaki T., Sawada H., Maruyama Y., Okuma M.
High expression of c-kit in K562YO cells due to the prolonged half-life of its mRNA: the effects of modification with serine/threonine kinase signals.
Blood 85:1496-1503(1995)

Cross-references
Cell line databases/resources MCCL; MCC:0000263
Encyclopedic resources Wikidata; Q54899422
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number21