ID   IB3-1
AC   CVCL_0338
SY   IB3
DR   BTO; BTO:0004445
DR   CLO; CLO_0004329
DR   EFO; EFO_0001194
DR   MCCL; MCC:0000234
DR   ATCC; CRL-2777
DR   ATCC; JHU-52
DR   BCRJ; 0114
DR   ChEMBL-Cells; CHEMBL4295410
DR   ChEMBL-Targets; CHEMBL4296439
DR   PubChem_Cell_line; CVCL_0338
DR   Wikidata; Q54897163
RX   PubMed=1380129;
RX   PubMed=1849726;
RX   PubMed=7679117;
RX   PubMed=15463957;
RX   PubMed=16512671;
RX   PubMed=18441018;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/i/cell-lines-detail-527.html
CC   Sequence variation: Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Heterozygous (PubMed=15463957).
CC   Sequence variation: Mutation; HGNC; 1884; CFTR; Simple; p.Trp1282Ter (c.3846G>A); ClinVar=VCV000007129; Zygosity=Heterozygous (PubMed=15463957).
CC   Transformant: Ad12-SV40 hybrid virus.
CC   Omics: Proteome analysis by 2D-DE/MS.
CC   Discontinued: ATCC; CRL-2777; true.
CC   Discontinued: ATCC; JHU-52; true.
ST   Source(s): ATCC=CRL-2777
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 8,12,13
ST   D16S539: 9,11
ST   D5S818: 11,12,13
ST   D7S820: 11,12
ST   TH01: 8,9.3
ST   TPOX: 8,9
ST   vWA: 15,18
DI   NCIt; C2975; Cystic fibrosis
DI   ORDO; Orphanet_586; Cystic fibrosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   7Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 21
//
RX   PubMed=1380129; DOI=10.1038/358581a0;
RA   Egan M., Flotte T.R., Afione S.A., Solow R., Zeitlin P.L., Carter B.J.,
RA   Guggino W.B.;
RT   "Defective regulation of outwardly rectifying Cl- channels by protein
RT   kinase A corrected by insertion of CFTR.";
RL   Nature 358:581-584(1992).
//
RX   PubMed=1849726; DOI=10.1165/ajrcmb/4.4.313;
RA   Zeitlin P.L., Lu L., Rhim J.S., Cutting G.R., Stetten G., Kieffer K.A.,
RA   Craig R., Guggino W.B.;
RT   "A cystic fibrosis bronchial epithelial cell line: immortalization by
RT   adeno-12-SV40 infection.";
RL   Am. J. Respir. Cell Mol. Biol. 4:313-319(1991).
//
RX   PubMed=7679117; DOI=10.1016/S0021-9258(18)53762-5;
RA   Flotte T.R., Afione S.A., Solow R., Drumm M.L., Markakis D.,
RA   Guggino W.B., Zeitlin P.L., Carter B.J.;
RT   "Expression of the cystic fibrosis transmembrane conductance regulator
RT   from a novel adeno-associated virus promoter.";
RL   J. Biol. Chem. 268:3781-3790(1993).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.;
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//
RX   PubMed=16512671; DOI=10.1021/pr050319o;
RA   Singh O.V., Vij N., Mogayzel P.J. Jr., Jozwik C., Pollard H.B.,
RA   Zeitlin P.L.;
RT   "Pharmacoproteomics of 4-phenylbutyrate-treated IB3-1 cystic fibrosis
RT   bronchial epithelial cells.";
RL   J. Proteome Res. 5:562-571(2006).
//
RX   PubMed=18441018; DOI=10.1194/jlr.M700388-JLR200; PMCID=PMC2444007;
RA   Andersson C., Al-Turkmani M.R., Savaille J.E., Alturkmani R.,
RA   Katrangi W., Cluette-Brown J.E., Zaman M.M., Laposata M.,
RA   Freedman S.D.;
RT   "Cell culture models demonstrate that CFTR dysfunction leads to
RT   defective fatty acid composition and metabolism.";
RL   J. Lipid Res. 49:1692-1700(2008).
//