ID   GT1-7
AC   CVCL_0281
AS   CVCL_8221
DR   BTO; BTO:0002708
DR   MCCL; MCC:0000172
DR   BCRJ; 0095
DR   Lonza; 687
DR   Millipore; SCC116
DR   TOKU-E; 4052
DR   Wikidata; Q54871828
RX   PubMed=1714837;
RX   PubMed=2196069;
RX   PubMed=10830297;
RX   PubMed=18406727;
CC   Characteristics: Exhibits high levels of Gnrh1 expression and secretes GnRH in response to depolarization.
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Misspelling: GTI-7; Note=Occasionally.
CC   Derived from site: In situ; Brain, hypothalamus; UBERON=UBERON_0001898.
CC   Cell type: GnRH neuron; CL=CL_0011111.
CC   Breed/subspecies: (C57BL/6J x BALB/cJ) F2 transgenic with rat Gnrh1 promoter-Tg(SV40).
ST   Source(s): Millipore=SCC116
ST   Mouse STR 1-1: 17
ST   Mouse STR 1-2: 19
ST   Mouse STR 11-2: 16,18
ST   Mouse STR 12-1: 16,17
ST   Mouse STR 13-1: 16.2,17
ST   Mouse STR 15-3: 22.3,23.3
ST   Mouse STR 17-2: 15
ST   Mouse STR 18-3: 16,17
ST   Mouse STR 19-2: 12,13
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 14
ST   Mouse STR 4-2: 20.3,21.3
ST   Mouse STR 5-5: 13,17
ST   Mouse STR 6-4: 17,18
ST   Mouse STR 6-7: 17
ST   Mouse STR 7-1: 26.2
ST   Mouse STR 8-1: 13,16
ST   Mouse STR X-1: 25,28
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_6235 ! GT1
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 21
//
RX   PubMed=1714837; DOI=10.1210/endo-129-3-1584;
RA   Wetsel W.C., Mellon P.L., Weiner R.I., Negro-Vilar A.;
RT   "Metabolism of pro-luteinizing hormone-releasing hormone in
RT   immortalized hypothalamic neurons.";
RL   Endocrinology 129:1584-1595(1991).
//
RX   PubMed=2196069; DOI=10.1016/0896-6273(90)90028-E;
RA   Mellon P.L., Windle J.J., Goldsmith P.C., Padula C.A., Roberts J.L.,
RA   Weiner R.I.;
RT   "Immortalization of hypothalamic GnRH neurons by genetically targeted
RT   tumorigenesis.";
RL   Neuron 5:1-10(1990).
//
RX   PubMed=10830297; DOI=10.1210/endo.141.6.7494;
RA   Maggi R., Pimpinelli F., Molteni L., Milani M., Martini L., Piva F.;
RT   "Immortalized luteinizing hormone-releasing hormone neurons show a
RT   different migratory activity in vitro.";
RL   Endocrinology 141:2105-2112(2000).
//
RX   PubMed=18406727; DOI=10.1016/1043-2760(95)00228-6;
RA   Wierman M.E., Fang Z.-Q., Kepa J.K.;
RT   "GnRH gene expression in neuronal cell lines.";
RL   Trends Endocrinol. Metab. 7:60-65(1996).
//