ID   GLC-4
AC   CVCL_0279
SY   GLC 4; GLC4
DR   BTO; BTO_0002385
DR   MCCL; MCC:0000170
DR   cancercelllines; CVCL_0279
DR   ChEMBL-Cells; CHEMBL3307807
DR   ChEMBL-Targets; CHEMBL612707
DR   Cosmic; 1429646
DR   Cosmic; 1998274
DR   Cosmic; 2239121
DR   GEO; GSM536324
DR   IARC_TP53; 11273
DR   Progenetix; CVCL_0279
DR   PubChem_Cell_line; CVCL_0279
DR   Wikidata; Q54835912
RX   PubMed=1320893;
RX   PubMed=1657425;
RX   PubMed=3028613;
RX   PubMed=3040227;
RX   PubMed=8980384;
RX   PubMed=9559344;
RX   PubMed=10025956;
RX   PubMed=10408787;
RX   PubMed=10709110;
RX   PubMed=15150577;
RX   PubMed=20615970;
CC   Doubling time: 26 hours (PubMed=3028613); 16.9 hours (PubMed=8980384).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Glu (c.394A>G); ClinVar=VCV000376626; Zygosity=Unspecified (PubMed=10408787).
CC   Omics: Array-based CGH.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 23
//
RX   PubMed=1320893; DOI=10.1159/000163712;
RA   Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M.,
RA   Carney D.N., Bepler G., Roebroek A.J.M., van de Ven W.J.M.,
RA   Burbach J.P.H.;
RT   "Expression of the vasopressin and gastrin-releasing peptide genes in
RT   small cell lung carcinoma cell lines.";
RL   Pathobiology 60:136-142(1992).
//
RX   PubMed=1657425; DOI=10.1007/BF00685823;
RA   de Jong S., Zijlstra J.G., Mulder N.H., de Vries E.G.E.;
RT   "Lack of cross-resistance to fostriecin in a human small-cell lung
RT   carcinoma cell line showing topoisomerase II-related drug resistance.";
RL   Cancer Chemother. Pharmacol. 28:461-464(1991).
//
RX   PubMed=3028613;
RA   Zijlstra J.G., de Vries E.G.E., Mulder N.H.;
RT   "Multifactorial drug resistance in an adriamycin-resistant human small
RT   cell lung carcinoma cell line.";
RL   Cancer Res. 47:1780-1784(1987).
//
RX   PubMed=3040227;
RA   Meijer C., Mulder N.H., Timmer-Bosscha H., Zijlstra J.G.,
RA   de Vries E.G.E.;
RT   "Role of free radicals in an adriamycin-resistant human small cell
RT   lung cancer cell line.";
RL   Cancer Res. 47:4613-4617(1987).
//
RX   PubMed=8980384; DOI=10.1038/bjc.1996.647; PMCID=PMC2074800;
RA   Withoff S., de Vries E.G.E., Keith W.N., Nienhuis E.F.,
RA   van der Graaf W.T.A., Uges D.R.A., Mulder N.H.;
RT   "Differential expression of DNA topoisomerase II alpha and -beta in
RT   P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines
RT   of the human SCLC cell line GLC4.";
RL   Br. J. Cancer 74:1869-1876(1996).
//
RX   PubMed=9559344; DOI=10.1002/(SICI)1098-2264(199804)21:4<326::AID-GCC6>3.0.CO;2-0;
RA   Mulligan L.M., Timmer T., Ivanchuk S.M., Campling B.G., Young L.C.,
RA   Rabbitts P.H., Sundaresan V., Hofstra R.M.W., Eng C.;
RT   "Investigation of the genes for RET and its ligand complex, GDNF/GFR
RT   alpha-I, in small cell lung carcinoma.";
RL   Genes Chromosomes Cancer 21:326-332(1998).
//
RX   PubMed=10025956; DOI=10.1016/S0014-5793(98)01716-5;
RA   Vernhet L., Courtois A., Allain N., Payen L., Anger J.-P.,
RA   Guillouzo A., Fardel O.;
RT   "Overexpression of the multidrug resistance-associated protein (MRP1)
RT   in human heavy metal-selected tumor cells.";
RL   FEBS Lett. 443:321-325(1999).
//
RX   PubMed=10408787; DOI=10.1097/00019606-199903000-00002;
RA   Hayes V.M., Bleeker W., Verlind E., Timmer T., Karrenbeld A.,
RA   Plukker J.T., Marx M.P., Hofstra R.M.W., Buys C.H.C.M.;
RT   "Comprehensive TP53-denaturing gradient gel electrophoresis mutation
RT   detection assay also applicable to archival paraffin-embedded
RT   tissue.";
RL   Diagn. Mol. Pathol. 8:2-10(1999).
//
RX   PubMed=10709110; DOI=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O;
RA   McLaughlin P.M.J., Helfrich W., Kok K., Mulder M., Hu S.W.,
RA   Brinker M.G.L., Ruiters M.H.J., de Leij L.F.M.H., Buys C.H.C.M.;
RT   "The ubiquitin-activating enzyme E1-like protein in lung cancer cell
RT   lines.";
RL   Int. J. Cancer 85:871-876(2000).
//
RX   PubMed=15150577; DOI=10.1038/sj.bjc.6601863; PMCID=PMC2409533;
RA   Boonstra R., Timmer-Bosscha H., van Echten-Arends J.,
RA   van der Kolk D.M., van den Berg A., de Jong B., Tew K.D., Poppema S.,
RA   de Vries E.G.E.;
RT   "Mitoxantrone resistance in a small cell lung cancer cell line is
RT   associated with ABCA2 upregulation.";
RL   Br. J. Cancer 90:2411-2417(2004).
//
RX   PubMed=20615970; DOI=10.1073/pnas.1008132107; PMCID=PMC2919980;
RA   Voortman J., Lee J.-H., Killian J.K., Suuriniemi M., Wang Y.-H.,
RA   Lucchi M., Smith W.I. Jr., Meltzer P.S., Wang Y.-S., Giaccone G.;
RT   "Array comparative genomic hybridization-based characterization of
RT   genetic alterations in pulmonary neuroendocrine tumors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:13040-13045(2010).
//