ID   GEO
AC   CVCL_0271
SY   Geo; HCT-GEO; HCT GEO
DR   BTO; BTO:0002892
DR   MCCL; MCC:0000162
DR   cancercelllines; CVCL_0271
DR   Cell_Model_Passport; SIDM00068
DR   ColonAtlas; GEO
DR   Cosmic; 738930
DR   Cosmic; 889529
DR   Cosmic; 1131685
DR   Cosmic; 1479567
DR   Cosmic; 1708407
DR   Cosmic-CLP; 2164691
DR   DepMap; ACH-002394
DR   GDSC; 2164691
DR   GEO; GSM1448176
DR   PharmacoDB; Geo_403_2019
DR   PRIDE; PXD005235
DR   Wikidata; Q54835723
RX   PubMed=2835152;
RX   PubMed=3349466;
RX   PubMed=6578361;
RX   PubMed=7329817;
RX   PubMed=7761852;
RX   PubMed=17363507;
RX   PubMed=20570890;
RX   PubMed=25926053;
RX   PubMed=28854368;
RX   PubMed=30894373;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Microsatellite instability: Instable (MSI) (PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Cys344fs*110 (c.1030delT); Zygosity=Homozygous (Cosmic-CLP=2164691; DepMap=ACH-002394).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu1536Ter (c.4606G>T); ClinVar=VCV001050551; Zygosity=Homozygous (Cosmic-CLP=2164691; DepMap=ACH-002394).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (PubMed=20570890; Cosmic-CLP=2164691; DepMap=ACH-002394).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative phosphoproteome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=61.65%; Native American=2.66%; East Asian, North=1.33%; East Asian, South=0%; South Asian=0%; European, North=19.42%; European, South=14.94% (PubMed=30894373).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): PubMed=25926053
ST   Amelogenin: X
ST   D13S317: 8,12
ST   D16S539: 12
ST   D21S11: 29
ST   D5S818: 12
ST   D7S820: 10,11,11.1
ST   TH01: 8
ST   TPOX: 8
ST   vWA: 15
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 29
//
RX   PubMed=2835152;
RA   Boyd D., Florent G., Kim P., Brattain M.G.;
RT   "Determination of the levels of urokinase and its receptor in human
RT   colon carcinoma cell lines.";
RL   Cancer Res. 48:3112-3116(1988).
//
RX   PubMed=3349466;
RA   Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.;
RT   "Epithelial polarity, villin expression, and enterocytic
RT   differentiation of cultured human colon carcinoma cells: a survey of
RT   twenty cell lines.";
RL   Cancer Res. 48:1936-1942(1988).
//
RX   PubMed=6578361; DOI=10.1093/jnci/71.4.663;
RA   Marks M.E., Danbury B.H., Miller C.A. III, Brattain M.G.;
RT   "Cell surface proteins and glycoproteins from biologically different
RT   human colon carcinoma cell lines.";
RL   J. Natl. Cancer Inst. 71:663-671(1983).
//
RX   PubMed=7329817;
RA   Brattain M.G., Brattain D.E., Fine W.D., Khaled F.M., Marks M.E.,
RA   Kimball P.M., Arcolano L.A., Danbury B.H.;
RT   "Initiation and characterization of cultures of human colonic
RT   carcinoma with different biological characteristics utilizing feeder
RT   layers of confluent fibroblasts.";
RL   Oncodev. Biol. Med. 2:355-366(1981).
//
RX   PubMed=7761852; DOI=10.1126/science.7761852;
RA   Markowitz S.D., Wang J., Myeroff L.L., Parsons R., Sun L.-Z.,
RA   Lutterbaugh J.D., Fan R.S., Zborowska E., Kinzler K.W., Vogelstein B.,
RA   Brattain M.G., Willson J.K.V.;
RT   "Inactivation of the type II TGF-beta receptor in colon cancer cells
RT   with microsatellite instability.";
RL   Science 268:1336-1338(1995).
//
RX   PubMed=17363507; DOI=10.1158/1535-7163.MCT-06-0555;
RA   Wang J., Kuropatwinski K., Hauser J., Rossi M.R., Zhou Y.-F., Conway A.,
RA   Kan J.L.C., Gibson N.W., Willson J.K.V., Cowell J.K., Brattain M.G.;
RT   "Colon carcinoma cells harboring PIK3CA mutations display resistance
RT   to growth factor deprivation induced apoptosis.";
RL   Mol. Cancer Ther. 6:1143-1150(2007).
//
RX   PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192;
RA   Janakiraman M., Vakiani E., Zeng Z.-S., Pratilas C.A., Taylor B.S.,
RA   Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C.M.,
RA   Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M.,
RA   Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.;
RT   "Genomic and biological characterization of exon 4 KRAS mutations in
RT   human cancer.";
RL   Cancer Res. 70:5901-5911(2010).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//
RX   PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010;
RA   Roumeliotis T.I., Williams S.P., Goncalves E., Alsinet C.,
RA   Del Castillo Velasco-Herrera M., Aben N., Ghavidel F.Z., Michaut M.,
RA   Schubert M., Price S., Wright J.C., Yu L., Yang M., Dienstmann R.,
RA   Guinney J., Beltrao P., Brazma A., Pardo M., Stegle O., Adams D.J.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.;
RT   "Genomic determinants of protein abundance variation in colorectal
RT   cancer cells.";
RL   Cell Rep. 20:2201-2214(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//