Cellosaurus cell line Beta-TC-tet (CVCL

Cellosaurus Beta-TC-tet (CVCL_0185)

Cross-references
Cell line name	Beta-TC-tet
Synonyms	BetaTCtet; betaTC-tet
Accession	CVCL_0185
Resource Identification Initiative	To cite this cell line use: Beta-TC-tet (RRID:CVCL_0185)
Comments	Characteristics: Expression of the SV40 T-antigen is under the control of the tet operator sequence. Shows growth arrest and further differentiation upon addition of 5 ng/ml tetracycline (PubMed=7724601). Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006. Cell type: Pancreatic beta cell; CL=CL_0000169.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C3HeB/FeJ transgenic.
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Conditionally immortalized cell line
Web pages	http://www.cells-talk.com/index.php/page/copelibrary?key=betaTC-tet
Publications	PubMed=7724601; DOI=10.1073/pnas.92.8.3576; PMCID=PMC42210 Efrat S., Fusco-DeMane D., Lemberg H., Al Emran O., Wang X.-R. Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc. Natl. Acad. Sci. U.S.A. 92:3576-3580(1995) PubMed=11900281; DOI=10.1080/15604280212526; PMCID=PMC2478570 Landesman-Milo D., Efrat S. Growth factor-dependent proliferation of the pancreatic beta-cell line betaTC-tet: an assay for beta-cell mitogenic factors. Int. J. Exp. Diabetes Res. 3:69-74(2002)
Cell line collections (Providers)	ATCC; CRL-3237
Cell line databases/resources	MCCL; MCC:0000076
Encyclopedic resources	Wikidata; Q54796105
Entry history
Entry creation	04-Apr-2012
Last entry update	19-Dec-2024
Version number	14