ID   BT-20
AC   CVCL_0178
SY   BT 20; BT20
DR   BTO; BTO:0001466
DR   CLO; CLO_0002041
DR   EFO; EFO_0001092
DR   MCCL; MCC:0000069
DR   CLDB; cl493
DR   CLDB; cl494
DR   CLDB; cl495
DR   AddexBio; C0006014/4910
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-TABM-157
DR   ATCC; CRL-7912
DR   ATCC; HTB-19
DR   BioSample; SAMN03471671
DR   BioSample; SAMN03472738
DR   BioSample; SAMN10987894
DR   cancercelllines; CVCL_0178
DR   CCRID; 1101HUM-PUMC000335
DR   Cell_Model_Passport; SIDM00893
DR   ChEMBL-Cells; CHEMBL3307766
DR   ChEMBL-Targets; CHEMBL613870
DR   CLS; 300130
DR   Cosmic; 687463
DR   Cosmic; 871137
DR   Cosmic; 904350
DR   Cosmic; 906801
DR   Cosmic; 934519
DR   Cosmic; 979719
DR   Cosmic; 991332
DR   Cosmic; 997914
DR   Cosmic; 1010923
DR   Cosmic; 1017159
DR   Cosmic; 1018465
DR   Cosmic; 1046932
DR   Cosmic; 1047701
DR   Cosmic; 1136370
DR   Cosmic; 1287931
DR   Cosmic; 1289382
DR   Cosmic; 1434946
DR   Cosmic; 1524352
DR   Cosmic; 1603190
DR   Cosmic; 1609471
DR   Cosmic; 1995348
DR   Cosmic; 2009507
DR   Cosmic; 2036672
DR   Cosmic; 2301232
DR   Cosmic; 2301522
DR   Cosmic; 2307195
DR   Cosmic; 2318378
DR   Cosmic; 2361352
DR   Cosmic-CLP; 906801
DR   DepMap; ACH-000536
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 906801
DR   GEO; GSM184390
DR   GEO; GSM184391
DR   GEO; GSM350505
DR   GEO; GSM421860
DR   GEO; GSM459725
DR   GEO; GSM783945
DR   GEO; GSM827574
DR   GEO; GSM847197
DR   GEO; GSM847452
DR   GEO; GSM843445
DR   GEO; GSM843446
DR   GEO; GSM886891
DR   GEO; GSM887956
DR   GEO; GSM1053689
DR   GEO; GSM1172940
DR   GEO; GSM1238127
DR   GEO; GSM1374406
DR   GEO; GSM1374407
DR   GEO; GSM1401673
DR   GEO; GSM1669629
DR   IARC_TP53; 3
DR   IBRC; C10149
DR   IGRhCellID; BT20
DR   KCLB; 60061
DR   LiGeA; CCLE_451
DR   LINCS_HMS; 50105
DR   LINCS_LDP; LCL-1476
DR   Lonza; 114
DR   NCBI_Iran; C434
DR   PharmacoDB; BT20_108_2019
DR   PRIDE; PXD008222
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0178
DR   PubChem_Cell_line; CVCL_0178
DR   SLKBase; 3481
DR   TOKU-E; 693
DR   Wikidata; Q52392673
RX   CelloPub=CLPUB00423;
RX   DOI=10.1007/978-1-4757-0019-0_7;
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RX   PubMed=833871;
RX   PubMed=3518877;
RX   PubMed=4831449;
RX   PubMed=6220172;
RX   PubMed=6582512;
RX   PubMed=7017212;
RX   PubMed=7459858;
RX   PubMed=10969801;
RX   PubMed=11414198;
RX   PubMed=11789735;
RX   PubMed=12661003;
RX   PubMed=12800145;
RX   PubMed=13611537;
RX   PubMed=16397213;
RX   PubMed=16541312;
RX   PubMed=17157791;
RX   PubMed=19582160;
RX   PubMed=19593635;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=21778573;
RX   PubMed=22460905;
RX   PubMed=22585861;
RX   PubMed=23151021;
RX   PubMed=23601657;
RX   PubMed=24094812;
RX   PubMed=24176112;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25892236;
RX   PubMed=25960936;
RX   PubMed=25984343;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=28889351;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=35839778;
WW   https://en.wikipedia.org/wiki/BT-20_(cell_line)
WW   https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/BT20.html
WW   http://dpsc.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=BT-20
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=BT-20
WW   https://lincs.hms.harvard.edu/resources/reagents/icbp43/
WW   https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: EGFR genetic alteration cell panel (ATCC TCP-1027).
CC   Part of: GrayJW breast cancer cell line panel.
CC   Part of: ICBP43 breast cancer cell line panel.
CC   Part of: KuDOS 95 cell line panel.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Part of: PI3K genetic alteration cell panel (ATCC TCP-1028).
CC   Population: Caucasian.
CC   Doubling time: 70 hours (PubMed=25984343); 66.15 hours (GrayJW panel).
CC   HLA typing: A*02:01,24:02; B*15:01,38:01; C*03:03,12:03; DQB1*06:03,06:03; DRB1*04:05,13:06 (PubMed=25960936).
CC   HLA typing: A*24:02,24:02; B*15:01,67:02; C*03:03,12:03; DQA1*01:02,01:02; DQB1*06:11,06:11; DRB1*04:05,13:01 (PubMed=26589293).
CC   HLA typing: A*24:02:01,24:03:01; B*15:01:01,14:01:01; C*03:03:01,12:03:01; DPB1*04:01:01G,06:01:01G; DQA1*01:03:01,03:01:01; DQB1*03:02:01,06:03:01; DRB1*04:04:01,13:01:01 (CLS=300130).
CC   Microsatellite instability: Stable (MSS) (PubMed=12661003; Sanger).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=19593635; ATCC).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro539Arg (c.1616C>G); ClinVar=VCV000376243; Zygosity=Heterozygous (PubMed=19593635; PubMed=28889351; ATCC).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (PubMed=19593635; PubMed=28889351; ATCC).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Ile388Ser (c.1163T>G); ClinVar=VCV000665312; Zygosity=Homozygous (PubMed=19593635).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Pro515Leu (c.1544C>T); Zygosity=Heterozygous (PubMed=19593635).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Lys132Gln (c.394A>C); ClinVar=VCV000376628; Zygosity=Homozygous (PubMed=16541312; PubMed=28889351; ATCC).
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: miRNA expression profiling.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: shRNA library screening.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=5.3%; Native American=0%; East Asian, North=9.54%; East Asian, South=0%; South Asian=0%; European, North=43.6%; European, South=41.56% (PubMed=30894373).
CC   Discontinued: ATCC; CRL-7912; true.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
ST   Source(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; KCLB; PubMed=25877200; PubMed=28889351
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11
ST   D16S539: 11 (PubMed=25877200)
ST   D16S539: 11,14 (AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; PubMed=28889351)
ST   D18S51: 17
ST   D19S433: 15
ST   D21S11: 28,29
ST   D2S1338: 19
ST   D3S1358: 17
ST   D5S818: 12
ST   D7S820: 10
ST   D8S1179: 12
ST   FGA: 22,24
ST   Penta D: 10,11
ST   Penta E: 11,13
ST   TH01: 7,9.3
ST   TPOX: 11
ST   vWA: 16,17
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   74Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 44
//
RX   CelloPub=CLPUB00423;
RA   Morrison B.J.;
RT   "Breast cancer stem cells: tumourspheres and implications for therapy.";
RL   Thesis PhD (2010), Griffith University, Australia.
//
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RT   carcinogenesis.";
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//
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RA   Leibovitz A.;
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RT   human tumor cell lines of various tissue origins.";
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RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
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RT   control of immunohistochemical assay of HER-2/neu expression in breast
RT   cancer.";
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RT   "Identification of microsatellite instability and mismatch repair gene
RT   mutations in breast cancer cell lines.";
RL   Genes Chromosomes Cancer 37:29-35(2003).
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RT   pancreatic cancer cell lines targets the neuregulin/NRG1 gene.";
RL   Genes Chromosomes Cancer 37:333-345(2003).
//
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RT   "Cultivation of human breast carcinomas.";
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//
RX   PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853;
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RA   van den Ouweland A., Merajver S.D., Ethier S.P., Schutte M.;
RT   "BRCA1 mutation analysis of 41 human breast cancer cell lines reveals
RT   three new deleterious mutants.";
RL   Cancer Res. 66:41-45(2006).
//
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RA   Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.;
RT   "Thirteen new p53 gene mutants identified among 41 human breast cancer
RT   cell lines.";
RL   Breast Cancer Res. Treat. 99:97-101(2006).
//
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RA   Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T.,
RA   Clark L., Bayani N., Coppe J.-P., Tong F., Speed T., Spellman P.T.,
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RT   "A collection of breast cancer cell lines for the study of
RT   functionally distinct cancer subtypes.";
RL   Cancer Cell 10:515-527(2006).
//
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RA   Kwei K.A., Hernandez-Boussard T., Wang P., Gazdar A.F., Minna J.D.,
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RT   tumor models and provides a resource for cancer gene discovery.";
RL   PLoS ONE 4:E6146-E6146(2009).
//
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RA   Hollestelle A., Nagel J.H.A., Smid M., Lam S., Elstrodt F.,
RA   Wasielewski M., Ng S.S., French P.J., Peeters J.K., Rozendaal M.J.,
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RA   den Bakker M.A., Foekens J.A., Martens J.W.M., Schutte M.;
RT   "Distinct gene mutation profiles among luminal-type and basal-type
RT   breast cancer cell lines.";
RL   Breast Cancer Res. Treat. 121:53-64(2010).
//
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RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
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RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
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RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
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RA   Chavez K.J., Garimella S.V., Lipkowitz S.;
RT   "Triple negative breast cancer cell lines: one tool in the search for
RT   better treatment of triple negative breast cancer.";
RL   Breast Dis. 32:35-48(2010).
//
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RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
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RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
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RT   "Essential gene profiles in breast, pancreatic, and ovarian cancer
RT   cells.";
RL   Cancer Discov. 2:172-189(2012).
//
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RA   Reis-Filho J.S., Tutt A.;
RT   "Molecular characterisation of cell line models for triple-negative
RT   breast cancers.";
RL   BMC Genomics 13:619.1-619.14(2012).
//
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RT   "miRNA expression profiling of 51 human breast cancer cell lines
RT   reveals subtype and driver mutation-specific miRNAs.";
RL   Breast Cancer Res. 15:R33.1-R33.17(2013).
//
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RA   Hu M., Chan D.A., Ethier S.P., van 't Veer L.J., Polyak K.,
RA   McCormick F., Gray J.W.;
RT   "Glutamine sensitivity analysis identifies the xCT antiporter as a
RT   common triple-negative breast tumor therapeutic target.";
RL   Cancer Cell 24:450-465(2013).
//
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RA   Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M.,
RA   Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S.,
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RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
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//
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