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Cellosaurus BCBL-1 (CVCL_0165)

[Text version]
Cell line name BCBL-1
Synonyms BCBL1; BCBL; Body Cavity Based Lymphoma-1
Accession CVCL_0165
Resource Identification Initiative To cite this cell line use: BCBL-1 (RRID:CVCL_0165)
Comments Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Doubling time: ~50 hours (DSMZ=ACC-683).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Sequence variations
HLA typing Source: DSMZCellDive=ACC-683
Class I
HLA-AA*01:01:01,31:01:02
HLA-BB*51:01:01,55:01:01
HLA-CC*03:03:01,15:02:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*03:01:01,04:01:01
HLA-DQDQA1*01:02:01,01:04:01
DQB1*05:03:01,06:02:01
HLA-DRDRA*01:01:01,01:02:03
DRB1*14:54:01,15:01:01
Disease Primary effusion lymphoma (NCIt: C6915)
Primary effusion lymphoma (ORDO: Orphanet_48686)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-683

Markers:
AmelogeninX
CSF1PO12
D2S133819,25
D3S135816,17
D5S81811,13
D7S8208,9
D8S117916
D13S31711,12
D16S53912
D18S5113
D19S43314
D21S1129,30
FGA20,22
Penta D9,13
Penta E14
TH019,9.3
TPOX9
vWA17

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=BCBL-1
https://tcpaportal.org/mclp/
Publications

PubMed=8612236; DOI=10.1038/nm0396-342
Renne R., Zhong W.-D., Herndier B.G., McGrath M.S., Abbey N.W., Kedes D.H., Ganem D.E.
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture.
Nat. Med. 2:342-346(1996)

PubMed=9375005; DOI=10.1006/viro.1997.8822
Picchio G.R., Sabbe R.E., Gulizia R.J., McGrath M.S., Herndier B.G., Mosier D.E.
The KSHV/HHV8-infected BCBL-1 lymphoma line causes tumors in SCID mice but fails to transmit virus to a human peripheral blood mononuclear cell graft.
Virology 238:22-29(1997)

PubMed=9766492; DOI=10.1038/sj.leu.2401160
Drexler H.G., Uphoff C.C., Gaidano G., Carbone A.
Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).
Leukemia 12:1507-1517(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15613351; DOI=10.1128/JVI.79.2.1244-1251.2005; PMCID=PMC538532
Fan W., Bubman D., Chadburn A., Harrington W.J. Jr., Cesarman E., Knowles D.M.
Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.
J. Virol. 79:1244-1251(2005)

PubMed=17121789; DOI=10.1128/JVI.01757-06; PMCID=PMC1797584
Burd C.E., Sin S.-H., Dittmer D.P.
Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.
J. Virol. 81:1912-1922(2007)

PubMed=17324269; DOI=10.1186/1471-2407-7-35; PMCID=PMC1810304
Ruff K.R., Puetter A., Levy L.S.
Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-beta1 and IL-6.
BMC Cancer 7:35.1-35.13(2007)

PubMed=19521981; DOI=10.1002/ijc.24521
Takahashi-Makise N., Suzu S., Hiyoshi M., Ohsugi T., Katano H., Umezawa K., Okada S.
Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway.
Int. J. Cancer 125:1464-1472(2009)

PubMed=19608668; DOI=10.3324/haematol.2009.007260; PMCID=PMC2719041
Boulanger E., Marchio A., Hong S.-S., Pineau P.
Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin genes in human herpesvirus 8-associated primary effusion lymphoma.
Haematologica 94:1170-1174(2009)

PubMed=21685375; DOI=10.1182/blood-2010-12-323659; PMCID=PMC3158728
Roy D., Sin S.-H., Damania B., Dittmer D.P.
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood 118:e32-e39(2011)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-3233
DSMZ; ACC-683
Cell line databases/resources MCCL; MCC:0000057
cancercelllines; CVCL_0165
DSMZCellDive; ACC-683
Lonza; 238
TOKU-E; 4070
Anatomy/cell type resources BTO; BTO:0002727
Biological sample resources BioSample; SAMN03473436
BioSamples; SAMEA365914
BioSamples; SAMEA365927
Encyclopedic resources Wikidata; Q54795334
Experimental variables resources EFO; EFO_0002048
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM33134
GEO; GSM38800
GEO; GSM38801
GEO; GSM634735
GEO; GSM710421
GEO; GSM710437
GEO; GSM1265856
GEO; GSM1265857
GEO; GSM1265858
GEO; GSM1265859
GEO; GSM1265860
GEO; GSM1265868
GEO; GSM3150238
Polymorphism and mutation databases Cosmic; 1238078
Cosmic; 1515185
Cosmic; 1588560
IARC_TP53; 26980
Progenetix; CVCL_0165
Proteomic databases PRIDE; PXD012087
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number29