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Cellosaurus 435.eB (CVCL_0124)

[Text version]
Cell line name 435.eB
Accession CVCL_0124
Resource Identification Initiative To cite this cell line use: 435.eB (RRID:CVCL_0124)
Comments Problematic cell line: Contaminated. Parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
Transfected with: HGNC; 3430; ERBB2.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Derived from metastatic site: Right buttock; hypodermis.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0417 (MDA-MB-435)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
Cross-references
Cell line databases/resources MCCL; MCC:0000016
Encyclopedic resources Wikidata; Q54603035
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number22