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Cellosaurus HMC-1 (CVCL_0003)

[Text version]
Cell line name HMC-1
Synonyms HMC1
Accession CVCL_0003
Resource Identification Initiative To cite this cell line use: HMC-1 (RRID:CVCL_0003)
Comments Doubling time: 3-4 days (PubMed=3131594).
Omics: Deep antibody staining analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Mast cell; CL=CL_0000097.
Sequence variations
  • Mutation; HGNC; 6342; KIT; Simple; p.Val560Gly (c.1679T>G); ClinVar=VCV000375916; Zygosity=Heterozygous (PubMed=7691885).
  • Mutation; HGNC; 6342; KIT; Simple; p.Asp816Val (c.2447A>T); ClinVar=VCV000013852; Zygosity=Heterozygous (PubMed=7691885).
Disease Mast cell leukemia (NCIt: C3169)
Mast cell leukemia (ORDO: Orphanet_98851)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4T80 (HMC-1 5C6)CVCL_H206 (HMC-1.1)CVCL_H205 (HMC-1.2)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-283

Markers:
AmelogeninX
CSF1PO10,13
D2S133817,25
D3S135815
D5S81812,13
D7S82010,11
D8S117912
D13S31710,11
D16S53910,12
D18S5114,20
D19S43314
D21S1129
FGA18,20
Penta D11
Penta E9,19
TH017,9.3
TPOX8,11
vWA17,19

Run an STR similarity search on this cell line
Web pages https://www.proteinatlas.org/learn/cellines
Publications

PubMed=3131594; DOI=10.1016/0145-2126(88)90050-1
Butterfield J.H., Weiler D.A., Dewald G.W., Gleich G.J.
Establishment of an immature mast cell line from a patient with mast cell leukemia.
Leuk. Res. 12:345-355(1988)

PubMed=7691885; DOI=10.1172/JCI116761; PMCID=PMC288334
Furitsu T., Tsujimura T., Tono T., Ikeda H., Kitayama H., Koshimizu U., Sugahara H., Butterfield J.H., Ashman L.K., Kanayama Y., Matsuzawa Y., Kitamura Y., Kanakura Y.
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
J. Clin. Invest. 92:1736-1744(1993)

PubMed=8191224; DOI=10.1111/j.1365-3083.1994.tb03404.x
Nilsson G., Blom T., Kusche-Gullberg M., Kjellen L., Butterfield J.H., Sundstrom C., Nilsson K., Hellman L.
Phenotypic characterization of the human mast-cell line HMC-1.
Scand. J. Immunol. 39:489-498(1994)

PubMed=8950460; DOI=10.1007/BF02505297
Weber S., Babina M., Kruger-Krasagakes S., Grutzkau A., Henz B.M.
A subclone (5C6) of the human mast cell line HMC-1 represents a more differentiated phenotype than the original cell line.
Arch. Dermatol. Res. 288:778-782(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=25149487; DOI=10.1007/978-1-4939-1173-8_8
Passante E.
Mast cell and basophil cell lines: a compendium.
Methods Mol. Biol. 1192:101-113(2014)

Cross-references
Cell line collections (Providers) DSMZ; ACC-283 - Discontinued
Cell line databases/resources MCCL; MCC:0000199
cancercelllines; CVCL_0003
DSMZCellDive; ACC-283
Lonza; 502
TOKU-E; 3534
Anatomy/cell type resources BTO; BTO:0001669
Biological sample resources BioSample; SAMN03473342
Chemistry resources ChEMBL-Cells; CHEMBL4295401
ChEMBL-Targets; CHEMBL4296432
PubChem_Cell_line; CVCL_0003
Encyclopedic resources Wikidata; Q54889906
Polymorphism and mutation databases Cosmic; 821806
Cosmic; 821913
Cosmic; 822147
Cosmic; 1122161
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number26