Cellosaurus logo
expasy logo

Cellosaurus UWB1.289+BRCA1 (CVCL_B078)

[Text version]
Cell line name UWB1.289+BRCA1
Accession CVCL_B078
Resource Identification Initiative To cite this cell line use: UWB1.289+BRCA1 (RRID:CVCL_B078)
Comments Part of: OCCP ovarian cancer cell line panel.
Population: Caucasian.
Characteristics: Due to the high expression of the transfected wild-type BRCA1 gene, this cell line is partially rescued in term of its response to DNA damage.
Doubling time: 20.0 hours (PubMed=17259345); ~36 hours (ATCC=CRL-2946).
Transfected with: HGNC; 1100; BRCA1.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Gene deletion; HGNC; 1100; BRCA1; Zygosity=Heterozygous (PubMed=17259345).
  • Mutation; HGNC; 1100; BRCA1; Simple; p.Asp825Glufs*21 (c.2475delC); ClinVar=VCV000037472; Zygosity=Heterozygous (PubMed=17259345).
Disease BRCA1-associated hereditary breast and ovarian cancer syndrome (NCIt: C36100)
Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B079 (UWB1.289)
Sex of cell Female
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2946; PubMed=25230021

Markers:
AmelogeninX
CSF1PO11
D2S133819
D3S135814,15
D5S81813
D7S8207,10
D8S117912
D13S3179
D16S53912
D18S5119
D19S43314,15
D21S1128,31
FGA22
Penta D10
Penta E8
TH019
TPOX9,11
vWA16,19

Run an STR similarity search on this cell line
Publications

PubMed=17259345; DOI=10.1158/1541-7786.MCR-06-0234
DelloRusso C., Welcsh P.L., Wang W.-X., Garcia R.L., King M.-C., Swisher E.M.
Functional characterization of a novel BRCA1-null ovarian cancer cell line in response to ionizing radiation.
Mol. Cancer Res. 5:35-45(2007)

PubMed=25230021; DOI=10.1371/journal.pone.0103988
Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:E103988-E103988(2014)

Cross-references
Cell line collections (Providers) ATCC; CRL-2946
Anatomy/cell type resources BTO; BTO:0006254
Encyclopedic resources Wikidata; Q54992391
Gene expression databases GEO; GSM1291154
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number16