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Cellosaurus SKOV3.ip1 (CVCL_0C84)

[Text version]
Cell line name SKOV3.ip1
Synonyms SKOV3-ip1; Skov3-ip1; SKOV3ip1; SKOV3IP1; SKOV3IP
Accession CVCL_0C84
Resource Identification Initiative To cite this cell line use: SKOV3.ip1 (RRID:CVCL_0C84)
Comments Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Omics: Deep proteome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Children:
CVCL_C4J9 (SKOV3.ip1 PEA-15-AA)CVCL_C4JA (SKOV3.ip1 PEA-15-DD)CVCL_C4JB (SKOV3.ip1 PEA-15-WT)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=8094034
Yu D.-H., Wolf J.K., Scanlon M., Price J.E., Hung M.-C.
Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A.
Cancer Res. 53:891-898(1993)

PubMed=23552738; DOI=10.1038/oncsis.2012.22
Lee J., Bartholomeusz C., Krishnamurthy S., Liu P., Saso H., LaFortune T.A., Hortobagyi G.N., Ueno N.T.
PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking beta-catenin.
Oncogenesis 1:e22.1-e22.11(2012)

PubMed=27561551; DOI=10.1038/ncomms12645
Coscia F., Watters K.M., Curtis M., Eckert M.A., Chiang C.-Y., Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Nat. Commun. 7:12645.1-12645.14(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0C84
Anatomy/cell type resources BTO; BTO:0006557
Encyclopedic resources Wikidata; Q54954770
Proteomic databases PRIDE; PXD003668
Entry history
Entry creation10-Apr-2015
Last entry update05-Oct-2023
Version number18