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Cellosaurus Beta-TC-6 (CVCL_0605)

[Text version]
Cell line name Beta-TC-6
Synonyms beta-TC-6; beta-TC6; beta TC6; BetaTC6; betaTC6
Accession CVCL_0605
Resource Identification Initiative To cite this cell line use: Beta-TC-6 (RRID:CVCL_0605)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11506.
Characteristics: Secretes insulin in response to glucose challenge. But this phenotype is unstable.
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: ChIP-seq epigenome analysis.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Mouse insulinoma (NCIt: C34053)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: (C57BL/6J x DBA/2J)F2 transgenic RIP1Tag2.
Hierarchy Children:
CVCL_JJ87 (Beta-TC-6-F7)
Category Transformed cell line
Publications

PubMed=7958492; DOI=10.2337/diab.43.12.1413
Knaack D., Fiore D.M., Surana M., Leiser M., Laurance M.E., Fusco-DeMane D., Hegre O.D., Fleischer N., Efrat S.
Clonal insulinoma cell line that stably maintains correct glucose responsiveness.
Diabetes 43:1413-1417(1994)

PubMed=7533732; DOI=10.2337/diab.44.3.306
Poitout V., Stout L.E., Armstrong M.B., Walseth T.F., Sorenson R.L., Robertson R.P.
Morphological and functional characterization of beta TC-6 cells -- an insulin-secreting cell line derived from transgenic mice.
Diabetes 44:306-313(1995)

PubMed=8697299
Poitout V., Olson L.K., Robertson R.P.
Insulin-secreting cell lines: classification, characteristics and potential applications.
Diabetes Metab. 22:7-14(1996)

Patent=US5773255
Laurance M.E., Knaack D., Fiore D.M., Hegre O.D.
Glucose responsive insulin secreting beta-cell lines and method for producing same.
Patent number US5773255, 30-Jun-1998

Cross-references
Cell line collections (Providers) ATCC; CRL-3605
ATCC; CRL-11506 - Discontinued
CLS; 305181
IZSLER; BS TCL 222
KCB; KCB 2010190YJ
Cell line databases/resources CLO; CLO_0001933
CCRID; 3101MOUSCSP5061
CCRID; 3101MOUTCM34
Lonza; 1688
Anatomy/cell type resources BTO; BTO:0003428
Chemistry resources ChEMBL-Cells; CHEMBL3308358
ChEMBL-Targets; CHEMBL614357
PubChem_Cell_line; CVCL_0605
Encyclopedic resources Wikidata; Q54796099
Gene expression databases GEO; GSE70960
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number21